Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine

doi:10.1038/s41467-018-08066-0

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-018-08066-0
	Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
	Batson, Sarah 1; de Chiara, Cesira 2; Majce, Vita 1,3; Lloyd, Adrian J.1; Gobec, Stanislav 3; Rea, Dean 1; Fulop, Vilmos 1; Thoroughgood, Christopher W.1; Simmons, Katie J.4; Dowson, Christopher G.1; Fishwick, Colin W. G.4; de Carvalho, Luiz Pedro S.2; Roper, David I.1
	2019-01-14
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2017
卷号	8
文章类型	Article
语种	英语
国家	England; Slovenia
英文摘要	D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine: D-alanine ligase. By a combination of structural, chemical and mechanistic studies here we show that the inhibition of D-alanine: D-alanine ligase by the antibiotic D-cycloserine proceeds via a distinct phosphorylated form of the drug. This mechanistic insight reveals a bimodal mechanism of action for a single antibiotic on different enzyme targets and has significance for the design of future inhibitor molecules based on this chemical structure.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000417054900006
WOS关键词	D-ALANINE LIGASE ; VANCOMYCIN RESISTANCE ; ANTIBACTERIAL DISCOVERY ; CRYSTAL-STRUCTURES ; ESCHERICHIA-COLI ; PHOSPHATE ; MECHANISM ; ENTEROCOCCI ; SYNTHETASE ; REFINEMENT
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/204165
专题	资源环境科学
作者单位	1.Univ Warwick, Sch Life Sci, Coventry CV4 7AL, W Midlands, England; 2.Francis Crick Inst, Mycobacterial Metab & Antibiot Res Lab, London NW1 1AT, England; 3.Univ Ljubljana, Dept Pharmaceut Chem, Fac Pharm, Askerceva 7, Ljubljana 1000, Slovenia; 4.Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
推荐引用方式 GB/T 7714	Batson, Sarah,de Chiara, Cesira,Majce, Vita,et al. Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine[J]. NATURE COMMUNICATIONS,2019,8.
APA	Batson, Sarah.,de Chiara, Cesira.,Majce, Vita.,Lloyd, Adrian J..,Gobec, Stanislav.,...&Roper, David I..(2019).Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.NATURE COMMUNICATIONS,8.
MLA	Batson, Sarah,et al."Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine".NATURE COMMUNICATIONS 8(2019).