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DOI | 10.1038/s41467-018-07913-4 |
Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis | |
Kale, Girish R.1,2; Yang, Xingbo3,4; Philippe, Jean-Marc1; Mani, Madhav3; Lenne, Pierre-Francois1; Lecuit, Thomas1,5 | |
2018-11-27 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | France; India; USA |
英文摘要 | During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanical forces affect E-cadherin adhesion and junction dynamics. During Drosophila embryo axis elongation, Myosin-II activity in the apico-medial and junctional cortex generates mechanical forces to drive junction remodeling. Here we report that the ratio between Vinculin and E-cadherin intensities acts as a ratiometric readout for these mechanical forces (load) at E-cadherin complexes. Medial Myosin-II loads E-cadherin complexes on all junctions, exerts tensile forces, and increases levels of E-cadherin. Junctional Myosin-II, on the other hand, biases the distribution of load between junctions of the same cell, exerts shear forces, and decreases the levels of E-cadherin. This work suggests distinct effects of tensile versus shear stresses on E-cadherin adhesion. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000451311000006 |
WOS关键词 | ALPHA-CATENIN ; ADHERENS JUNCTIONS ; CELL INTERCALATION ; PLANAR POLARITY ; ADHESION ; MYOSIN ; FORCE ; DYNAMICS ; MECHANICS ; REVEALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204136 |
专题 | 资源环境科学 |
作者单位 | 1.Aix Marseille Univ, Turing Ctr Living Syst, CNRS, IBDM UMR7288, F-13009 Marseille, France; 2.Natl Ctr Biol Sci, GKVK Campus,Bellary Rd, Bangalore 560065, Karnataka, India; 3.Northwestern Univ, 2145 Sheridan Rd, Evanston, IL 60208 USA; 4.Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA; 5.Coll France, 11 Pl Marcelin Berthelot, F-75005 Paris, France |
推荐引用方式 GB/T 7714 | Kale, Girish R.,Yang, Xingbo,Philippe, Jean-Marc,et al. Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Kale, Girish R.,Yang, Xingbo,Philippe, Jean-Marc,Mani, Madhav,Lenne, Pierre-Francois,&Lecuit, Thomas.(2018).Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis.NATURE COMMUNICATIONS,9. |
MLA | Kale, Girish R.,et al."Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis".NATURE COMMUNICATIONS 9(2018). |
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