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DOI | 10.1038/s41467-018-07415-3 |
Stable transgenerational epigenetic inheritance requires a DNA methylation-sensing circuit | |
Williams, Ben P.1; Gehring, Mary1,2 | |
2017-12-14 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Epigenetic states are stably propagated in eukaryotes. In plants, DNA methylation patterns are faithfully inherited over many generations but it is unknown how the dynamic activities of cytosine DNA methyltransferases and 5-methylcytosine DNA glycosylases interact to maintain epigenetic homeostasis. Here we show that a methylation-sensing gene regulatory circuit centered on a 5-methylcytosine DNA glycosylase gene is required for long-term epigenetic fidelity in Arabidopsis. Disrupting this circuit causes widespread methylation losses and abnormal phenotypes that progressively worsen over generations. In heterochromatin, these losses are counteracted such that methylation returns to a normal level over four generations. However, thousands of loci in euchromatin progressively lose DNA methylation between generations and remain unmethylated. We conclude that an actively maintained equilibrium between methylation and demethylation activities is required to ensure long-term stable inheritance of epigenetic information. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000417906400008 |
WOS关键词 | RNA-POLYMERASE V ; ARABIDOPSIS GENOME ; TANDEM REPEATS ; RECOMBINATION ; GENES ; METHYLTRANSFERASES ; DEMETHYLATION ; TRANSPOSONS ; PROMOTERS ; EPIGENOME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204111 |
专题 | 资源环境科学 |
作者单位 | 1.Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA; 2.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Williams, Ben P.,Gehring, Mary. Stable transgenerational epigenetic inheritance requires a DNA methylation-sensing circuit[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Williams, Ben P.,&Gehring, Mary.(2017).Stable transgenerational epigenetic inheritance requires a DNA methylation-sensing circuit.NATURE COMMUNICATIONS,8. |
MLA | Williams, Ben P.,et al."Stable transgenerational epigenetic inheritance requires a DNA methylation-sensing circuit".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
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