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DOI | 10.1038/s41467-018-07275-x |
The complete structure of an activated open sodium channel | |
Sula, Altin1; Booker, Jennifer1; Ng, Leo C. T.2; Naylor, Claire E.1; DeCaen, Paul G.2; Wallace, B. A.1 | |
2017-02-16 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | England; USA |
英文摘要 | Voltage-gated sodium channels (Navs) play essential roles in excitable tissues, with their activation and opening resulting in the initial phase of the action potential. The cycling of Navs through open, closed and inactivated states, and their closely choreographed relationships with the activities of other ion channels lead to exquisite control of intracellular ion concentrations in both prokaryotes and eukaryotes. Here we present the 2.45 angstrom resolution crystal structure of the complete NavMs prokaryotic sodium channel in a fully open conformation. A canonical activated conformation of the voltage sensor S4 helix, an open selectivity filter leading to an open activation gate at the intracellular membrane surface and the intracellular C-terminal domain are visible in the structure. It includes a heretofore unseen interaction motif between W77 of S3, the S4-S5 interdomain linker, and the C-terminus, which is associated with regulation of opening and closing of the intracellular gate. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000394225000001 |
WOS关键词 | C-TERMINAL DOMAIN ; CRYSTAL-STRUCTURE ; NACHBAC ; SOFTWARE ; SUITE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204097 |
专题 | 资源环境科学 |
作者单位 | 1.Univ London, Birkbeck Coll, Inst Struct & Mol Biol, Malet St, London WC1E 7HX, England; 2.Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, 320 E Super, Chicago, IL 60611 USA |
推荐引用方式 GB/T 7714 | Sula, Altin,Booker, Jennifer,Ng, Leo C. T.,et al. The complete structure of an activated open sodium channel[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Sula, Altin,Booker, Jennifer,Ng, Leo C. T.,Naylor, Claire E.,DeCaen, Paul G.,&Wallace, B. A..(2017).The complete structure of an activated open sodium channel.NATURE COMMUNICATIONS,8. |
MLA | Sula, Altin,et al."The complete structure of an activated open sodium channel".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
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