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DOI | 10.1038/s41467-018-07066-4 |
Pulmonary pericytes regulate lung morphogenesis | |
Kato, Katsuhiro1,2; Dieguez-Hurtado, Rodrigo1,2; Park, Do Young3,4,5; Hong, Seon Pyo3,4,5; Kato-Azuma, Sakiko1,2; Adams, Susanne1,2; Stehling, Martin6; Trappmann, Britta7; Wrana, Jeffrey L.8,9; Koh, Gou Young3,4,5; Adams, Ralf H.1,2 | |
2018-06-22 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; South Korea; Canada |
英文摘要 | Blood vessels are essential for blood circulation but also control organ growth, homeostasis, and regeneration, which has been attributed to the release of paracrine signals by endothelial cells. Endothelial tubules are associated with specialised mesenchymal cells, termed pericytes, which help to maintain vessel wall integrity. Here we identify pericytes as regulators of epithelial and endothelial morphogenesis in postnatal lung. Mice lacking expression of the Hippo pathway components YAP and TAZ in pericytes show defective alveologenesis. Mutant pericytes are present in normal numbers but display strongly reduced expression of hepatocyte growth factor leading to impaired activation of the c-Met receptor, which is expressed by alveolar epithelial cells. YAP and TAZ are also required for expression of angiopoietin-1 by pulmonary pericytes, which also controls hepatocyte growth factor expression and thereby alveologenesis in an autocrine fashion. These findings establish that pericytes have important, organ-specific signalling properties and coordinate the behavior of epithelial and vascular cells during lung morphogenesis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000436049500001 |
WOS关键词 | HEPATOCYTE GROWTH-FACTOR ; ENDOTHELIAL-CELLS ; BRONCHOPULMONARY DYSPLASIA ; VASCULAR MORPHOGENESIS ; BLOOD-VESSELS ; HIPPO PATHWAY ; ALVEOLARIZATION ; DIFFERENTIATION ; ANGIOPOIETIN-1 ; PROGENITORS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204094 |
专题 | 资源环境科学 |
作者单位 | 1.Max Planck Inst Mol Biomed, Dept Tissue Morphogenesis, D-48149 Munster, Germany; 2.Univ Munster, Fac Med, D-48149 Munster, Germany; 3.Inst for Basic Sci Korea, Ctr Vasc Res, Daejeon 34141, South Korea; 4.Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea; 5.Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon 34141, South Korea; 6.Max Planck Inst Mol Biomed, Electron Microscopy & Flow Cytometry Units, D-48149 Munster, Germany; 7.Max Planck Inst Mol Biomed, Bioact Mat Lab, D-48149 Munster, Germany; 8.Mt Sinai Hosp, Ctr Syst Biol, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada; 9.Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada |
推荐引用方式 GB/T 7714 | Kato, Katsuhiro,Dieguez-Hurtado, Rodrigo,Park, Do Young,et al. Pulmonary pericytes regulate lung morphogenesis[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Kato, Katsuhiro.,Dieguez-Hurtado, Rodrigo.,Park, Do Young.,Hong, Seon Pyo.,Kato-Azuma, Sakiko.,...&Adams, Ralf H..(2018).Pulmonary pericytes regulate lung morphogenesis.NATURE COMMUNICATIONS,9. |
MLA | Kato, Katsuhiro,et al."Pulmonary pericytes regulate lung morphogenesis".NATURE COMMUNICATIONS 9(2018). |
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