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DOI | 10.1038/s41467-018-07362-z |
Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1 | |
Rosner, Margit1; Ha Thi Thanh Pham1,2,3; Moriggl, Richard2,3,4; Hengstschlaeger, Markus1 | |
2017-09-19 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Austria |
英文摘要 | Controlled invasion is essential during many physiological processes, whereas its deregulation is a hallmark of cancer. Here we demonstrate that embryonic, induced pluripotent and amniotic fluid stem cells share the property to induce the invasion of primary somatic cells of various origins through insulin-like growth factor I (IGF-I)-or II (IGF-II)-mediated paracrine activation of mechanistic target of rapamycin complex 1 (mTORC1). We propose a model in which downstream of mTORC1 this stem cell-induced invasion is mediated by hypoxiainducible factor 1-alpha (HIF-1 alpha)-regulated matrix metalloproteinases. Manipulating the IGF signalling pathway in the context of teratoma formation experiments demonstrates that human stem cells use this mechanism to induce invasion and thereby attract cells from the microenvironment in vivo. In this study we have identified a so far unknown feature of human stem cells, which might play a role for the development of stem cell-derived tumours. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411166900008 |
WOS关键词 | HUMAN AMNIOTIC-FLUID ; SIGNAL INTEGRATION ; CANCER ; GROWTH ; FIBROBLASTS ; RECEPTOR ; MATRIX ; IGF ; MICROENVIRONMENT ; PROGRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204085 |
专题 | 资源环境科学 |
作者单位 | 1.Med Univ Vienna, Ctr Pathobiochem & Genet, Inst Med Genet, A-1090 Vienna, Austria; 2.Ludwig Boltzmann Inst Canc Res, A-1090 Vienna, Austria; 3.Univ Vet Med, Inst Anim Breeding & Genet, A-1210 Vienna, Austria; 4.Med Univ Vienna, A-1090 Vienna, Austria |
推荐引用方式 GB/T 7714 | Rosner, Margit,Ha Thi Thanh Pham,Moriggl, Richard,et al. Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Rosner, Margit,Ha Thi Thanh Pham,Moriggl, Richard,&Hengstschlaeger, Markus.(2017).Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.NATURE COMMUNICATIONS,8. |
MLA | Rosner, Margit,et al."Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1".NATURE COMMUNICATIONS 8(2017). |
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