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DOI | 10.1038/s41467-018-07079-z |
Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion | |
Gorelick-Ashkenazi, Anna1; Weiss, Ron1; Sapozhnikov, Lena1; Florentin, Anat1,2; Tarayrah-Ibraheim, Lama1; Dweik, Dima1; Yacobi-Sharon, Keren1; Arama, Eli1 | |
2018-07-18 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Israel; USA |
英文摘要 | Maintenance of tissue integrity during development and homeostasis requires the precise coordination of several cell-based processes, including cell death. In animals, the majority of such cell death occurs by apoptosis, a process mediated by caspase proteases. To elucidate the role of caspases in tissue integrity, we investigated the behavior of Drosophila epithelial cells that are severely compromised for caspase activity. We show that these cells acquire migratory and invasive capacities, either within 1-2 days following irradiation or spontaneously during development. Importantly, low levels of effector caspase activity, which are far below the threshold required to induce apoptosis, can potently inhibit this process, as well as a distinct, developmental paradigm of primordial germ cell migration. These findings may have implications for radiation therapy in cancer treatment. Furthermore, given the presence of caspases throughout metazoa, our results could imply that preventing unwanted cell migration constitutes an ancient non-apoptotic function of these proteases. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000439030400006 |
WOS关键词 | MATRIX METALLOPROTEINASES ; DROSOPHILA-MELANOGASTER ; SIGNALING PATHWAYS ; DEATH ; EVOLUTION ; MULTICELLULARITY ; METASTASIS ; CANCER ; CONSERVATION ; ACTIVATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204071 |
专题 | 资源环境科学 |
作者单位 | 1.Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel; 2.Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA |
推荐引用方式 GB/T 7714 | Gorelick-Ashkenazi, Anna,Weiss, Ron,Sapozhnikov, Lena,et al. Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Gorelick-Ashkenazi, Anna.,Weiss, Ron.,Sapozhnikov, Lena.,Florentin, Anat.,Tarayrah-Ibraheim, Lama.,...&Arama, Eli.(2018).Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion.NATURE COMMUNICATIONS,9. |
MLA | Gorelick-Ashkenazi, Anna,et al."Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion".NATURE COMMUNICATIONS 9(2018). |
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