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DOI | 10.1038/s41467-018-07044-w |
A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications | |
Winkler, Thomas W.1; Guenther, Felix1,2; Hoellerer, Simon1; Zimmermann, Martina1; Loos, Ruth J. F.3,4,5; Kutalik, Zoltan6,7; Heid, Iris M.1 | |
2018-05-16 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA; Switzerland |
英文摘要 | The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here, we adopt a joint view of adiposity traits in similar to 322,154 subjects (GIANT consortium). We classify 159 signals associated with body mass index (BMI), waist-to-hip ratio (WHR), or WHR adjusted for BMI (WHRadjBMI) at P < 5 x 10(-8), into four classes based on the direction of their effects on BMI and WHR. Our classes help differentiate adiposity genetics with respect to anthropometry, fat depots, and metabolic health. Class-specific Mendelian randomization reveals that variants associated with both WHR-decrease and BMI increase are linked to metabolically rather favorable adiposity through beneficial hip fat. Class-specific enrichment analyses implicate digestive systems as a pathway in adiposity genetics. Our results demonstrate that WHRadjBMI variants capture relevant effects of "unexpected fat distribution given the BMI" and that a joint view of the genetics underlying related phenotypes can inform on important biology. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000432280000002 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; BODY-MASS INDEX ; FAT ; TISSUE ; RISK ; ARCHITECTURE ; METAANALYSIS ; INSIGHTS ; DISEASE ; BIOLOGY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204058 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Regensburg, Dept Genet Epidemiol, D-93051 Regensburg, Germany; 2.Ludwig Maximilians Univ Munchen, Dept Stat, Stat Consulting Unit StaBLab, D-80539 Munich, Germany; 3.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA; 4.Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA; 5.Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA; 6.CHU Vaudois, Inst Social & Prevent Med IUMSP, CH-1010 Lausanne, Switzerland; 7.Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland |
推荐引用方式 GB/T 7714 | Winkler, Thomas W.,Guenther, Felix,Hoellerer, Simon,et al. A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Winkler, Thomas W..,Guenther, Felix.,Hoellerer, Simon.,Zimmermann, Martina.,Loos, Ruth J. F..,...&Heid, Iris M..(2018).A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications.NATURE COMMUNICATIONS,9. |
MLA | Winkler, Thomas W.,et al."A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications".NATURE COMMUNICATIONS 9(2018). |
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