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DOI | 10.1038/s41467-018-07064-6 |
In situ architecture of the algal nuclear pore complex | |
Mosalaganti, Shyamal1; Kosinski, Jan1,2; Albert, Sahradha3; Schaffer, Miroslava3; Strenkert, Daniela4; Salome, Patrice A.4; Merchant, Sabeeha S.4; Plitzko, Juergen M.3; Baumeister, Wolfgang3; Engel, Benjamin D.3; Beck, Martin1,5 | |
2018-06-18 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA |
英文摘要 | Nuclear pore complexes (NPCs) span the nuclear envelope and mediate nucleocytoplasmic exchange. They are a hallmark of eukaryotes and deeply rooted in the evolutionary origin of cellular compartmentalization. NPCs have an elaborate architecture that has been well studied in vertebrates. Whether this architecture is unique or varies significantly in other eukaryotic kingdoms remains unknown, predominantly due to missing in situ structural data. Here, we report the architecture of the algal NPC from the early branching eukaryote Chlamydomonas reinhardtii and compare it to the human NPC. We find that the inner ring of the Chlamydomonas NPC has an unexpectedly large diameter, and the outer rings exhibit an asymmetric oligomeric state that has not been observed or predicted previously. Our study provides evidence that the NPC is subject to substantial structural variation between species. The divergent and conserved features of NPC architecture provide insights into the evolution of the nucleocytoplasmic transport machinery. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435451000002 |
WOS关键词 | STRUCTURAL-ANALYSIS ; MOLECULAR ARCHITECTURE ; INNER RING ; EVOLUTION ; DYNAMICS ; REVEALS ; ORGANIZATION ; SOCIOLOGY ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204056 |
专题 | 资源环境科学 |
作者单位 | 1.European Mol Biol Lab, Struct & Computat Biol Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany; 2.DESY, European Mol Biol Lab, CSSB, Hamburg Unit, Notkestr 85, D-22607 Hamburg, Germany; 3.Max Planck Inst Biochem, Dept Mol Struct Biol, Klopferspitz 18, D-82152 Martinsried, Germany; 4.UCLA, Dept Chem & Biochem, Inst Genom & Prote, 607 Charles E Young Dr East, Los Angeles, CA 90095 USA; 5.European Mol Biol Lab, Cell Biol & Biophys Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany |
推荐引用方式 GB/T 7714 | Mosalaganti, Shyamal,Kosinski, Jan,Albert, Sahradha,et al. In situ architecture of the algal nuclear pore complex[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Mosalaganti, Shyamal.,Kosinski, Jan.,Albert, Sahradha.,Schaffer, Miroslava.,Strenkert, Daniela.,...&Beck, Martin.(2018).In situ architecture of the algal nuclear pore complex.NATURE COMMUNICATIONS,9. |
MLA | Mosalaganti, Shyamal,et al."In situ architecture of the algal nuclear pore complex".NATURE COMMUNICATIONS 9(2018). |
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