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DOI | 10.1038/s41467-018-06788-9 |
Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens | |
Ottenheimer, David1; Richard, Jocelyn M.2,4; Janak, Patricia H.1,2,3 | |
2018-10-19 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The ventral striatopallidal system, a basal ganglia network thought to convert limbic information into behavioral action, includes the nucleus accumbens (NAc) and the ventral pallidum (VP), typically described as a major output of NAc. Here, to investigate how reward-related information is transformed across this circuit, we measure the activity of neurons in NAc and VP when rats receive two highly palatable but differentially preferred rewards, allowing us to track the reward-specific information contained within the neural activity of each region. In VP, we find a prominent preference-related signal that flexibly reports the relative value of reward outcomes across multiple conditions. This reward-specific firing in VP is present in a greater proportion of the population and arises sooner following reward delivery than in NAc. Our findings establish VP as a preeminent value signaler and challenge the existing model of information flow in the ventral basal ganglia. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447697100008 |
WOS关键词 | DISTINCT NEURONAL POPULATIONS ; BASAL FOREBRAIN ; APPETITIVE BEHAVIORS ; SUBTHALAMIC NUCLEUS ; INCENTIVE SALIENCE ; PREFRONTAL CORTEX ; NEGATIVE CONTRAST ; STRIATAL NEURONS ; HEDONIC REWARD ; MOTOR SYSTEM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204041 |
专题 | 资源环境科学 |
作者单位 | 1.Johns Hopkins Univ, Johns Hopkins Sch Med, Solomon H Snyder Dept Neurosci, 725 N Wolfe St, Baltimore, MD 21205 USA; 2.Johns Hopkins Univ, Krieger Sch Arts & Sci, Dept Psychol & Brain Sci, 3400 N Charles St, Baltimore, MD 21218 USA; 3.Johns Hopkins Univ, Kavli Neurosci Discovery Inst, 3400 N Charles St, Baltimore, MD 21218 USA; 4.Univ Minnesota, Dept Neurosci, 321 Church St SE, Minneapolis, MN 55455 USA |
推荐引用方式 GB/T 7714 | Ottenheimer, David,Richard, Jocelyn M.,Janak, Patricia H.. Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Ottenheimer, David,Richard, Jocelyn M.,&Janak, Patricia H..(2018).Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens.NATURE COMMUNICATIONS,9. |
MLA | Ottenheimer, David,et al."Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens".NATURE COMMUNICATIONS 9(2018). |
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