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DOI | 10.1038/s41467-018-06358-z |
Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species | |
Baker, Kate S.1,2; Dallman, Timothy J.3; Field, Nigel4; Childs, Tristan5; Mitchell, Holly4; Day, Martin3; Weill, Francois-Xavier6; Lefevre, Sophie6; Tourdjman, Mathieu7; Hughes, Gwenda8; Jenkins, Claire3; Thomson, Nicholas2,9 | |
2018-04-13 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | England; France |
英文摘要 | Horizontal gene transfer has played a role in developing the global public health crisis of antimicrobial resistance (AMR). However, the dynamics of AMR transfer through bacterial populations and its direct impact on human disease is poorly elucidated. Here, we study parallel epidemic emergences of multiple Shigella species, a priority AMR organism, in men who have sex with men to gain insight into AMR emergence and spread. Using genomic epidemiology, we show that repeated horizontal transfer of a single AMR plasmid among Shigella enhanced existing and facilitated new epidemics. These epidemic patterns contrasted with slighter, slower increases in disease caused by organisms with vertically inherited (chromosomally encoded) AMR. This demonstrates that horizontal transfer of AMR directly affects epidemiological outcomes of globally important AMR pathogens and highlights the need for integration of genomic analyses into all areas of AMR research, surveillance and management. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000429921000019 |
WOS关键词 | ANTIBIOTIC-RESISTANCE ; SEXUAL TRANSMISSION ; GENOME ASSEMBLIES ; ENGLAND ; WALES ; MEN ; SURVEILLANCE ; INFECTIONS ; BURDEN ; RISK |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204023 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England; 2.Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England; 3.Publ Hlth England, Gastrointestinal Bacterial Reference Unit, Natl Infect Serv, London NW9 5HT, England; 4.UCL, Inst Global Hlth, Ctr Mol Epidemiol & Translat Res, London WC1E 6BT, England; 5.Publ Hlth England, Ctr Infect Dis Surveillance & Control, Natl Infect Serv, London NW9 5HT, England; 6.Inst Pasteur, Unite Bacteries Pathogenes Enter, F-75015 Paris, France; 7.Sante Publ France, F-94415 St Maurice, France; 8.Publ Hlth England, Natl Infect Serv, Dept HIV & STIs, London NW9 5HT, England; 9.London Sch Hyg & Trop Med, London WC1E 7HT, England |
推荐引用方式 GB/T 7714 | Baker, Kate S.,Dallman, Timothy J.,Field, Nigel,et al. Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Baker, Kate S..,Dallman, Timothy J..,Field, Nigel.,Childs, Tristan.,Mitchell, Holly.,...&Thomson, Nicholas.(2018).Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species.NATURE COMMUNICATIONS,9. |
MLA | Baker, Kate S.,et al."Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
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