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DOI | 10.1038/s41467-018-06472-y |
Programming molecular topologies from single-stranded nucleic acids | |
Qi, Xiaodong1,2; Zhang, Fei1,2; Su, Zhaoming3,4,5; Jiang, Shuoxing1,2; Han, Dongran6,7,9; Ding, Baoquan8; Liu, Yan1,2; Chiu, Wah3,4,5; Yin, Peng6,7; Yan, Hao1,2 | |
2018-11-02 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Molecular knots represent one of the most extraordinary topological structures in biological polymers. Creating highly knotted nanostructures with well-defined and sophisticated geometries and topologies remains challenging. Here, we demonstrate a general strategy to design and construct highly knotted nucleic acid nanostructures, each weaved from a single-stranded DNA or RNA chain by hierarchical folding in a prescribed order. Sets of DNA and RNA knots of two- or three-dimensional shapes have been designed and constructed (ranging from 1700 to 7500 nucleotides), and they exhibit complex topological features, with high crossing numbers (from 9 up to 57). These single-stranded DNA/RNA knots can be replicated and amplified enzymatically in vitro and in vivo. This work establishes a general platform for constructing nucleic acid nanostructures with complex molecular topologies. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000449069600001 |
WOS关键词 | STRUCTURAL DNA NANOTECHNOLOGY ; INFORMATION-STORAGE ; PARANEMIC COHESION ; KNOTTED DNA ; PROTEIN ; ARRAYS ; NANOSTRUCTURES ; TOPOISOMERASES ; LINKAGE ; CAPSIDS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204021 |
专题 | 资源环境科学 |
作者单位 | 1.Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA; 2.Arizona State Univ, Biodesign Inst, Ctr Mol Design & Biomimet, Tempe, AZ 85287 USA; 3.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 4.Stanford Univ, James H Clark Ctr, Stanford, CA 94305 USA; 5.SLAC Natl Accelerator Lab, SSRL, Div Cryo EM & Bioimaging, Menlo Pk, CA 94025 USA; 6.Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA; 7.Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA; 8.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R China; 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Qi, Xiaodong,Zhang, Fei,Su, Zhaoming,et al. Programming molecular topologies from single-stranded nucleic acids[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Qi, Xiaodong.,Zhang, Fei.,Su, Zhaoming.,Jiang, Shuoxing.,Han, Dongran.,...&Yan, Hao.(2018).Programming molecular topologies from single-stranded nucleic acids.NATURE COMMUNICATIONS,9. |
MLA | Qi, Xiaodong,et al."Programming molecular topologies from single-stranded nucleic acids".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
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