Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-06396-7 |
Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation | |
Lang, Tali1,14; Lee, Jacinta P. W.1; Elgass, Kirstin2; Pinar, Anita A.1,15; Tate, Michelle D.3,4; Aitken, Elizabeth H.5; Fan, Huapeng1; Creed, Sarah J.2; Deen, Nadia S.1; Traore, Daouda A. K.6,7; Mueller, Ivo8,9,10; Stanisic, Danielle11,16; Baiwog, Francesca S.12; Skene, Colin13; Wilce, Matthew C. J.6; Mansell, Ashley3,4; Morand, Eric F.1; Harris, James1 | |
2018-06-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Australia; Mali; France; Papua N Guinea |
英文摘要 | Macrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well as having functions outside the immune system. MIF can promote inflammation through the induction of other cytokines, including TNF, IL-6, and IL-1 family cytokines. Here, we show that inhibition of MIF regulates the release of IL-1 alpha, IL-1 beta, and IL-18, not by affecting transcription or translation of these cytokines, but via activation of the NLRP3 inflammasome. MIF is required for the interaction between NLRP3 and the intermediate filament protein vimentin, which is critical for NLRP3 activation. Further, we demonstrate that MIF interacts with NLRP3, indicating a role for MIF in inflammasome activation independent of its role as a cytokine. These data advance our understanding of how MIF regulates inflammation and identify it as a factor critical for NLRP3 inflammasome activation. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000434644000002 |
WOS关键词 | INNATE IMMUNE-RESPONSES ; NALP3 INFLAMMASOME ; CRYSTAL-STRUCTURE ; FACTOR MIF ; IL-1-BETA PRODUCTION ; ANGSTROM RESOLUTION ; UP-REGULATION ; SEPTIC SHOCK ; IL-1 FAMILY ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204019 |
专题 | 资源环境科学 |
作者单位 | 1.Monash Univ, Rheumatol Res Grp, Ctr Inflammatory Dis, Sch Clin Sci,Fac Med Nursing & Hlth Sci,Monash Hl, Clayton, Vic 3168, Australia; 2.Monash Micro Imaging, Hudson Inst Med Res, Clayton, Vic 3168, Australia; 3.Hudson Inst Med Res, Ctr Innate Immun & Infect Dis, Clayton, Vic 3168, Australia; 4.Monash Univ, Dept Mol & Translat Sci, Clayton, Vic 3168, Australia; 5.Univ Melbourne, Peter Doherty Inst, Dept Med, Parkville, Vic 3800, Australia; 6.Monash Univ, Biomed Discovery Inst, Dept Biochem & Mol Biol, Clayton, Vic 3000, Australia; 7.USTTB, Fac Sci & Tech, Bamako, Mali; 8.Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic 3052, Australia; 9.Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia; 10.Inst Pasteur, Malaria Parasites & Hosts Unit, F-75015 Paris, France; 11.Walter & Eliza Hall Inst Med Res, Infect & Immun Div, Parkville, Vic 3000, Australia; 12.Papua New Guinea Inst Med Res, Madang, Papua N Guinea; 13.Univ Melbourne, Dept Chem, Parkville, Vic 3000, Australia; 14.Cabrini Inst Malvern, Szalmuk Family Dept Med Oncol, Malvern, Vic 3144, Australia; 15.Monash Univ, Dept Pharmacol, Fac Med Nursing & Hlth Sci, 9 Ancora Imparo Way, Clayton, Vic 3800, Australia; 16.Griffith Univ, Inst Glyc, Southport, Qld 4215, Australia |
推荐引用方式 GB/T 7714 | Lang, Tali,Lee, Jacinta P. W.,Elgass, Kirstin,et al. Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Lang, Tali.,Lee, Jacinta P. W..,Elgass, Kirstin.,Pinar, Anita A..,Tate, Michelle D..,...&Harris, James.(2018).Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation.NATURE COMMUNICATIONS,9. |
MLA | Lang, Tali,et al."Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论