Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-06550-1 |
Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis | |
Boucher, Joshua M.1,2,5; Clark, Ryan P.1; Chong, Diana C.3; Citrin, Kathryn M.1; Wylie, Lyndsay A.3; Bautch, Victoria L.1,2,3,4 | |
2017-06-07 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease. Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis. Here we show that dynamic regulation of mVEGFR1 stability and turnover in blood vessels impacts angiogenesis. mVEGFR1 is highly stable and constitutively internalizes from the plasma membrane. Post-translational palmitoylation of mVEGFR1 is a binary stabilization switch, and ligand engagement leads to depalmitoylation and lysosomal degradation. Trafficking of palmitoylation enzymes via Rab27a regulates mVEGFR1 stability, as reduced levels of Rab27a impaired palmitoylation of mVEGFR1, decreased its stability, and elevated blood vessel sprouting and in vivo angiogenesis. These findings identify a regulatory axis affecting blood vessel morphogenesis that highlights exquisite post-translational regulation of mVEGFR1 in its role as a molecular rheostat. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402805400001 |
WOS关键词 | TYROSINE KINASE ; SIGNAL-TRANSDUCTION ; PROTEIN STABILITY ; CELL-SURFACE ; PALMITOYLATION ; ACTIVATION ; CHEMOKINE ; MOUSE ; FLT1 ; LOCALIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204017 |
专题 | 资源环境科学 |
作者单位 | 1.Univ North Carolina Chapel Hill, Dept Biol, Chapel Hill, NC 27599 USA; 2.Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA; 3.Univ North Carolina Chapel Hill, Genet & Mol Biol Curriculum, Chapel Hill, NC 27599 USA; 4.Univ North Carolina Chapel Hill, McAllister Heart Inst, Chapel Hill, NC 27599 USA; 5.Maine Med Ctr, Res Inst, Ctr Mol Med, Scarborough, ME 04074 USA |
推荐引用方式 GB/T 7714 | Boucher, Joshua M.,Clark, Ryan P.,Chong, Diana C.,et al. Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Boucher, Joshua M.,Clark, Ryan P.,Chong, Diana C.,Citrin, Kathryn M.,Wylie, Lyndsay A.,&Bautch, Victoria L..(2017).Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis.NATURE COMMUNICATIONS,8. |
MLA | Boucher, Joshua M.,et al."Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论