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DOI | 10.1038/s41467-018-05989-6 |
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity | |
Schmid, Daniela1,2; Park, Chun Gwon1,2; Hartl, Christina A.1; Subedi, Nikita1; Cartwright, Adam N.1; Puerto, Regina Bou1; Zheng, Yiran3,4; Maiarana, James1; Freeman, Gordon J.1; Wucherpfennig, Kai W.1; Irvine, Darrell J.3,4,5; Goldberg, Michael S.1,2 | |
2017-11-23 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by concentrating their action on the cells of interest. Because attempts to target tumors directly have yielded limited benefit, we instead target endogenous immune cell subsets in the circulation that can migrate actively into tumors. We describe antibody-targeted nanoparticles that bind to CD8(+) T cells in the blood, lymphoid tissues, and tumors of mice. PD-1(+) T cells are successfully targeted in the circulation and tumor. The delivery of an inhibitor of TGF beta signaling to PD-1-expressing cells extends the survival of tumor-bearing mice, whereas free drugs have no effect at such doses. This modular platform also enables PD-1-targeted delivery of a TLR7/8 agonist to the tumor microenvironment, increasing the proportion of tumor-infiltrating CD8(+) T cells and sensitizing tumors to subsequent anti-PD-1. Targeted delivery of immunotherapy to defined subsets of endogenous leukocytes may be superior to administration of free drugs. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000416229300033 |
WOS关键词 | TGF-BETA ; IN-VIVO ; TUMOR MICROENVIRONMENT ; CANCER-IMMUNOTHERAPY ; DENDRITIC CELLS ; DRUG-DELIVERY ; THERAPY ; MELANOMA ; ANTIBODY ; PEMBROLIZUMAB |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203973 |
专题 | 资源环境科学 |
作者单位 | 1.Dana Farber Canc Inst, Dept Canc Immunol & Virol, Boston, MA 02215 USA; 2.Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA 02215 USA; 3.MIT, Dept Biol Engn, Cambridge, MA 02139 USA; 4.Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA; 5.Howard Hughes Med Inst, Chevy Chase, MD 20815 USA |
推荐引用方式 GB/T 7714 | Schmid, Daniela,Park, Chun Gwon,Hartl, Christina A.,et al. T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Schmid, Daniela.,Park, Chun Gwon.,Hartl, Christina A..,Subedi, Nikita.,Cartwright, Adam N..,...&Goldberg, Michael S..(2017).T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity.NATURE COMMUNICATIONS,8. |
MLA | Schmid, Daniela,et al."T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
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