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DOI | 10.1038/s41467-018-05943-6 |
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria | |
Pietras, Zbigniew1,2; Wojcik, Magdalena A.1,3; Borowski, Lukasz S.1,3; Szewczyk, Maciej1,3; Kulinski, Tomasz M.1; Cysewski, Dominik1; Stepien, Piotr P.1,3; Dziembowski, Andrzej1,3; Szczesny, Roman J.1,3 | |
2018-07-02 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Poland |
英文摘要 | The GC skew in vertebrate mitochondrial genomes results in synthesis of RNAs that are prone to form G-quadruplexes (G4s). Such RNAs, although mostly non-coding, are transcribed at high rates and are degraded by an unknown mechanism. Here we describe a dedicated mechanism of degradation of G4-containing RNAs, which is based on cooperation between mitochondrial degradosome and quasi-RNA recognition motif (qRRM) protein GRSF1. This cooperation prevents accumulation of G4-containing transcripts in human mitochondria. In vitro reconstitution experiments show that GRSF1 promotes G4 melting that facilitates degradosome-mediated decay. Among degradosome and GRSF1 regulated transcripts we identified one that undergoes post-transcriptional modification. We show that GRSF1 proteins form a distinct qRRM group found only in vertebrates. The appearance of GRSF1 coincided with changes in the mitochondrial genome, which allows the emergence of G4-containing RNAs. We propose that GRSF1 appearance is an evolutionary adaptation enabling control of G4 RNA. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000436958500005 |
WOS关键词 | HUMAN POLYNUCLEOTIDE PHOSPHORYLASE ; BINDING-PROTEIN ; GENE-EXPRESSION ; HSUV3P HELICASE ; SUV3 HELICASE ; GRANULES ; IDENTIFICATION ; TRANSCRIPTION ; GENOME ; SEQUENCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203962 |
专题 | 资源环境科学 |
作者单位 | 1.Polish Acad Sci, Inst Biochem & Biophys, Lab RNA Biol & Funct Genom, Pawinskiego 5A, PL-02106 Warsaw, Poland; 2.Int Inst Mol & Cell Biol, Lab Prot Struct, Ks Trojdena 4, PL-02109 Warsaw, Poland; 3.Univ Warsaw, Inst Genet & Biotechnol, Fac Biol, Pawinskiego 5A, PL-02106 Warsaw, Poland |
推荐引用方式 GB/T 7714 | Pietras, Zbigniew,Wojcik, Magdalena A.,Borowski, Lukasz S.,et al. Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Pietras, Zbigniew.,Wojcik, Magdalena A..,Borowski, Lukasz S..,Szewczyk, Maciej.,Kulinski, Tomasz M..,...&Szczesny, Roman J..(2018).Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.NATURE COMMUNICATIONS,9. |
MLA | Pietras, Zbigniew,et al."Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria".NATURE COMMUNICATIONS 9(2018). |
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