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DOI | 10.1038/s41467-018-05484-y |
IRF8-dependent molecular complexes control the Th9 transcriptional program | |
Humblin, Etienne1,2; Thibaudin, Marion1,2; Chalmin, Fanny2; Derangere, Valentin1,2,3; Limagne, Emeric2,3; Richard, Corentin1,3; Flavell, Richard A.4,5; Chevrier, Sandy3,6; Ladoire, Sylvain1,2,3,7; Berger, Helene1,2; Boidot, Romain2,3,6; Apetoh, Lionel2,7; Vegran, Frederique2,3; Ghiringhelli, Francois1,2,3,7 | |
2017-12-12 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | France; USA |
英文摘要 | Interferon regulatory factors (IRF) have critical functions in lymphoid development and in immune response regulation. Although many studies have described the function of IRF4 in CD4(+) T cells, few have focused on the IRF4 homologue, IRF8. Here, we show that IRF8 is required for Th9 differentiation in vitro and in vivo. IRF8 functions through a transcription factor complex consisting of IRF8, IRF4, PU. 1 and BATF, which binds to DNA and boosts Il9 transcription. By contrast, IRF8 deficiency promotes the expression of other genes such as Il4, as IRF8 dimerises with the transcriptional repressor ETV6 and inhibits Il4 expression. In vivo, IRF8 is essential for the anti-tumour effects of Th9 cells in mouse melanoma models. Our results show that IRF8 complexes boost the Th9 program and repress Il4 expression to modulate Th9 cell differentiation, thereby implicating IRF8 as a potential therapeutic target to affect Th9 responses in cancer therapy. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000417702300036 |
WOS关键词 | SEQUENCE-BINDING-PROTEIN ; INTERFERON REGULATORY FACTOR-8 ; CHIP-SEQ DATA ; T-CELLS ; GENE-EXPRESSION ; FAMILY PROTEINS ; MYELOID CELLS ; WEB-SERVER ; TGF-BETA ; RNA-SEQ |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203956 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Bourgogne Franche Comte, F-21000 Dijon, France; 2.INSERM, Ctr Rech, LNC UMR1231, F-21000 Dijon, France; 3.Ctr Georges Francois Leclerc, Platform Transfer Canc Biol, F-21000 Dijon, France; 4.Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06510 USA; 5.Howard Hughes Med Inst, Chevy Chase, MD 20815 USA; 6.Ctr Georges Francois Leclerc, Dept Biol & Pathol Tumours, F-21000 Dijon, France; 7.Ctr Georges Francois Leclerc, Dept Med Oncol, F-21000 Dijon, France |
推荐引用方式 GB/T 7714 | Humblin, Etienne,Thibaudin, Marion,Chalmin, Fanny,et al. IRF8-dependent molecular complexes control the Th9 transcriptional program[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Humblin, Etienne.,Thibaudin, Marion.,Chalmin, Fanny.,Derangere, Valentin.,Limagne, Emeric.,...&Ghiringhelli, Francois.(2017).IRF8-dependent molecular complexes control the Th9 transcriptional program.NATURE COMMUNICATIONS,8. |
MLA | Humblin, Etienne,et al."IRF8-dependent molecular complexes control the Th9 transcriptional program".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
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