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DOI | 10.1038/s41467-018-05703-6 |
Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling | |
Barca-Mayo, Olga1,2; Pons-Espinal, Meritxell1; Follert, Philipp1; Armirotti, Andrea3; Berdondini, Luca2; Tonelli, Davide De Pietri1 | |
2017-02-10 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Italy |
英文摘要 | Circadian rhythms are controlled by a network of clock neurons in the central pacemaker, the suprachiasmatic nucleus (SCN). Core clock genes, such as Bmal1, are expressed in SCN neurons and in other brain cells, such as astrocytes. However, the role of astrocytic clock genes in controlling rhythmic behaviour is unknown. Here we show that ablation of Bmal1 in GLAST-positive astrocytes alters circadian locomotor behaviour and cognition in mice. Specifically, deletion of astrocytic Bmal1 has an impact on the neuronal clock through GABA signalling. Importantly, pharmacological modulation of GABAA-receptor signalling completely rescues the behavioural phenotypes. Our results reveal a crucial role of astrocytic Bmal1 for the coordination of neuronal clocks and propose a new cellular target, astrocytes, for neuropharmacology of transient or chronic perturbation of circadian rhythms, where alteration of astrocytic clock genes might contribute to the impairment of the neurobehavioural outputs such as cognition. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000394044400001 |
WOS关键词 | RAT SUPRACHIASMATIC NUCLEUS ; HIPPOCAMPUS-DEPENDENT MEMORY ; TANDEM MASS-SPECTROMETRY ; CORE CIRCADIAN CLOCK ; LIQUID-CHROMATOGRAPHY ; CEREBROSPINAL-FLUID ; ACTIVITY RHYTHMS ; SHORT-TERM ; NEURONS ; GLUTAMATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203938 |
专题 | 资源环境科学 |
作者单位 | 1.Fdn Ist Italiano Tecnol, Neurosci & Brain Technol Dept, Neurobiol miRNA Lab, Via Morego 30, I-16163 Genoa, Italy; 2.Fdn Ist Italiano Tecnol, Neurosci & Brain Technol Dept, Lab NetS3, Via Morego 30, I-16163 Genoa, Italy; 3.Fdn Ist Italiano Tecnol, PharmaChem D3, Dept Drug Discovery & Dev, Via Morego 30, I-16163 Genoa, Italy |
推荐引用方式 GB/T 7714 | Barca-Mayo, Olga,Pons-Espinal, Meritxell,Follert, Philipp,et al. Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Barca-Mayo, Olga,Pons-Espinal, Meritxell,Follert, Philipp,Armirotti, Andrea,Berdondini, Luca,&Tonelli, Davide De Pietri.(2017).Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling.NATURE COMMUNICATIONS,8. |
MLA | Barca-Mayo, Olga,et al."Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling".NATURE COMMUNICATIONS 8(2017). |
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