GSTDTAP  > 资源环境科学
DOI10.1038/s41467-018-05618-2
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
Han, Xuexiang1,2,3; Li, Yiye1,2; Xu, Ying1,2; Zhao, Xiao1,2; Zhang, Yinlong1,2; Yang, Xiao1,2; Wang, Yongwei4; Zhao, Ruifang1,2; Anderson, Gregory J.5; Zhao, Yuliang1,2; Nie, Guangjun1,2
2018-08-23
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2018
卷号9
文章类型Article
语种英语
国家Peoples R China; Australia
英文摘要

Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological obstacle, but also offer a potential target for anti-tumour therapy. Here, we construct a tumour microenvironment-responsive nanosystem, based on PEGylated polyethylenimine-coated gold nanoparticles, and utilise it to co-deliver all-trans retinoic acid (ATRA, an inducer of PSC quiescence) and siRNA targeting heat shock protein 47 (HSP47, a collagen-specific molecular chaperone) to re-educate PSCs. The nanosystem simultaneously induces PSC quiescence and inhibits ECM hyperplasia, thereby promoting drug delivery to pancreatic tumours and significantly enhancing the anti-tumour efficacy of chemotherapeutics. Our combination strategy to restore homoeostatic stromal function by targeting activated PSCs represents a promising approach to improving the efficacy of chemotherapy and other therapeutic modalities in a wide range of stroma-rich tumours.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000442521500015
WOS关键词ASSEMBLED GOLD NANOPARTICLES ; COLLAGEN-SPECIFIC CHAPERONE ; A-COUPLED LIPOSOMES ; DUCTAL ADENOCARCINOMA ; SIRNA DELIVERY ; RETINOIC ACID ; EXTRACELLULAR-MATRIX ; CANCER MODEL ; HSP47 SIRNA ; IN-VITRO
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
URL查看原文
引用统计
被引频次:281[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/203925
专题资源环境科学
作者单位1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China;
4.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China;
5.Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, Herston, Qld 4029, Australia
推荐引用方式
GB/T 7714
Han, Xuexiang,Li, Yiye,Xu, Ying,et al. Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem[J]. NATURE COMMUNICATIONS,2018,9.
APA Han, Xuexiang.,Li, Yiye.,Xu, Ying.,Zhao, Xiao.,Zhang, Yinlong.,...&Nie, Guangjun.(2018).Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem.NATURE COMMUNICATIONS,9.
MLA Han, Xuexiang,et al."Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem".NATURE COMMUNICATIONS 9(2018).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Han, Xuexiang]的文章
[Li, Yiye]的文章
[Xu, Ying]的文章
百度学术
百度学术中相似的文章
[Han, Xuexiang]的文章
[Li, Yiye]的文章
[Xu, Ying]的文章
必应学术
必应学术中相似的文章
[Han, Xuexiang]的文章
[Li, Yiye]的文章
[Xu, Ying]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。