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DOI | 10.1038/s41467-018-05618-2 |
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem | |
Han, Xuexiang1,2,3; Li, Yiye1,2; Xu, Ying1,2; Zhao, Xiao1,2; Zhang, Yinlong1,2; Yang, Xiao1,2; Wang, Yongwei4; Zhao, Ruifang1,2; Anderson, Gregory J.5; Zhao, Yuliang1,2; Nie, Guangjun1,2 | |
2018-08-23 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; Australia |
英文摘要 | Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological obstacle, but also offer a potential target for anti-tumour therapy. Here, we construct a tumour microenvironment-responsive nanosystem, based on PEGylated polyethylenimine-coated gold nanoparticles, and utilise it to co-deliver all-trans retinoic acid (ATRA, an inducer of PSC quiescence) and siRNA targeting heat shock protein 47 (HSP47, a collagen-specific molecular chaperone) to re-educate PSCs. The nanosystem simultaneously induces PSC quiescence and inhibits ECM hyperplasia, thereby promoting drug delivery to pancreatic tumours and significantly enhancing the anti-tumour efficacy of chemotherapeutics. Our combination strategy to restore homoeostatic stromal function by targeting activated PSCs represents a promising approach to improving the efficacy of chemotherapy and other therapeutic modalities in a wide range of stroma-rich tumours. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000442521500015 |
WOS关键词 | ASSEMBLED GOLD NANOPARTICLES ; COLLAGEN-SPECIFIC CHAPERONE ; A-COUPLED LIPOSOMES ; DUCTAL ADENOCARCINOMA ; SIRNA DELIVERY ; RETINOIC ACID ; EXTRACELLULAR-MATRIX ; CANCER MODEL ; HSP47 SIRNA ; IN-VITRO |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203925 |
专题 | 资源环境科学 |
作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; 4.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China; 5.Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, Herston, Qld 4029, Australia |
推荐引用方式 GB/T 7714 | Han, Xuexiang,Li, Yiye,Xu, Ying,et al. Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Han, Xuexiang.,Li, Yiye.,Xu, Ying.,Zhao, Xiao.,Zhang, Yinlong.,...&Nie, Guangjun.(2018).Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem.NATURE COMMUNICATIONS,9. |
MLA | Han, Xuexiang,et al."Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem".NATURE COMMUNICATIONS 9(2018). |
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