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DOI | 10.1038/s41467-018-05603-9 |
Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates | |
Nakazawa, Shingo1,2; Mizuno, Hidenobu1,2,3; Iwasato, Takuji1,2 | |
2018-08-06 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | Proper neuronal circuit function relies on precise dendritic projection, which is established through activity-dependent refinement during early postnatal development. Here we revealed dynamics of dendritic refinement in the mammalian brain by conducting long-term imaging of the neonatal mouse barrel cortex. By "retrospective" analyses, we identified "prospective" barrel-edge spiny stellate (SS) neurons in early neonates, which had an apical dendrite and primitive basal dendrites (BDs). These neurons retracted the apical dendrite gradually and established strong BD orientation bias through continuous "dendritic tree" turnover. A greater chance of survival was given to BD trees emerged in the barrel-center side, where thalamocortical axons (TCAs) cluster. When the spatial bias of TCA inputs to SS neurons was lost, BD tree turnover was suppressed, and most BD trees became stable and elaborated mildly. Thus, barrel-edge SS neurons could establish the characteristic BD projection pattern through differential dynamics of dendritic trees induced by spatially biased inputs. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000440777000036 |
WOS关键词 | RAT BARREL CORTEX ; NMDA RECEPTOR ; LAYER 4 ; CEREBRAL-CORTEX ; SOMATOSENSORY CIRCUIT ; SPINY NEURONS ; PLASTICITY ; GROWTH ; NEOCORTEX ; SINGLE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203919 |
专题 | 资源环境科学 |
作者单位 | 1.NIG, Div Neurogenet, Mishima, Shizuoka 4118540, Japan; 2.SOKENDAI Grad Univ Adv Studies, Dept Genet, Mishima, Shizuoka 4118540, Japan; 3.Kumamoto Univ, IRCMS, Kumamoto 8600811, Japan |
推荐引用方式 GB/T 7714 | Nakazawa, Shingo,Mizuno, Hidenobu,Iwasato, Takuji. Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Nakazawa, Shingo,Mizuno, Hidenobu,&Iwasato, Takuji.(2018).Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates.NATURE COMMUNICATIONS,9. |
MLA | Nakazawa, Shingo,et al."Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates".NATURE COMMUNICATIONS 9(2018). |
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