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DOI | 10.1038/s41467-018-05149-w |
Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes | |
An, Jung-Ung1; Song, Yong-Seok1; Kim, Kyoung-Rok1; Ko, Yoon-Joo2; Yoon, Do-Young1; Oh, Deok-Kun1 | |
2018-01-09 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | South Korea |
英文摘要 | Hepoxilins (HXs) and trioxilins (TrXs) are involved in physiological processes such as inflammation, insulin secretion and pain perception in human. They are metabolites of polyunsaturated fatty acids (PUFAs), including arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid, formed by 12-lipoxygenase (LOX) and epoxide hydrolase (EH) expressed by mammalian cells. Here, we identify ten types of HXs and TrXs, produced by the prokaryote Myxococcus xanthus, of which six types are new, namely, HXB5, HXD3, HXE3, TrXB5, TrXD3 and TrXE3. We succeed in the biotransformation of PUFAs into eight types of HXs (>35% conversion) and TrXs (>10% conversion) by expressing M. xanthus 12-LOX or 11-LOX with or without EH in Escherichia coli. We determine 11-hydroxy-eicosatetraenoic acid, HXB3, HXB4, HXD3, TrXB3 and TrXD3 as potential peroxisome proliferator-activated receptor-gamma partial agonists. These findings may facilitate physiological studies and drug development based on lipid mediators. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419658100027 |
WOS关键词 | ACTIVATED RECEPTOR-GAMMA ; PPAR-GAMMA ; NEUTROPHIL MIGRATION ; EPOXIDE HYDROLASES ; SYNTHASE ACTIVITY ; ARACHIDONIC-ACID ; LIGAND ; A(3) ; LIPOXYGENASE ; AGONISTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203916 |
专题 | 资源环境科学 |
作者单位 | 1.Konkuk Univ, Dept Integrat Biosci & Biotechnol, 120 Neungdong Ro, Seoul 05029, South Korea; 2.Seoul Natl Univ, Natl Ctr Interuniv Res Facil NCIRF, 1 Gwanak Ro, Seoul 08826, South Korea |
推荐引用方式 GB/T 7714 | An, Jung-Ung,Song, Yong-Seok,Kim, Kyoung-Rok,et al. Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes[J]. NATURE COMMUNICATIONS,2018,9. |
APA | An, Jung-Ung,Song, Yong-Seok,Kim, Kyoung-Rok,Ko, Yoon-Joo,Yoon, Do-Young,&Oh, Deok-Kun.(2018).Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes.NATURE COMMUNICATIONS,9. |
MLA | An, Jung-Ung,et al."Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes".NATURE COMMUNICATIONS 9(2018). |
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