中文版 | English
GSTDTAP  > 资源环境科学
DOI10.1038/s41467-018-05252-y
Identification of nine new susceptibility loci for endometrial cancer
O&1; 39;Mara, Tracy A.2
2018-08-09
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2018
卷号9
文章类型Article
语种英语
国家Australia; Belgium; USA; Germany; England; Canada; Sweden; Norway; Poland; Cyprus; Italy; Peoples R China
英文摘要

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000441157600001
WOS关键词GENOME-WIDE ASSOCIATION ; LD SCORE REGRESSION ; BODY-MASS INDEX ; BREAST-CANCER ; MENDELIAN RANDOMIZATION ; GENOTYPE IMPUTATION ; RISK LOCI ; FAMILY-HISTORY ; VARIANTS ; METAANALYSIS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
URL查看原文
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/203904
专题资源环境科学
作者单位1.QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld 4006, Australia;
2.Univ Leuven, Univ Hosp KU Leuven, Div Gynecol Oncol, Dept Obstet & Gynecol, B-3000 Leuven, Belgium;
3.John Hunter Hosp, Hunter Med Res Inst, Newcastle, NSW 2305, Australia;
4.Univ Newcastle, Ctr Informat Based Med, Callaghan, NSW 2308, Australia;
5.Univ Newcastle, Sch Biomed Sci & Pharm, Discipline Med Genet, Fac Hlth, Callaghan, NSW 2308, Australia;
6.Univ Newcastle, Sch Med & Publ Hlth, Ctr Clin Epidemiol & Biostat, Callaghan, NSW 2308, Australia;
7.Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98109 USA;
8.Univ Wisconsin Milwaukee, Zilber Sch Publ Hlth, Milwaukee, WI 53205 USA;
9.Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Gynecol & Obstet, Comprehens Canc Ctr ER EMN, D-91054 Erlangen, Germany;
10.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA;
11.Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England;
12.Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany;
13.Univ Tubingen, D-72074 Tubingen, Germany;
14.German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany;
15.German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany;
16.German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany;
17.Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany;
18.Univ Melbourne, Dept Clin Pathol, Melbourne, Vic 3010, Australia;
19.Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia;
20.Royal Melbourne Hosp, Genet Med & Family Canc Clin, Parkville, Vic 3010, Australia;
21.Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia;
22.Heidelberg Univ, Dept Obstet & Gynecol, D-69120 Heidelberg, Germany;
23.German Canc Res Ctr, Mol Epidemiol Grp, C080, D-69120 Heidelberg, Germany;
24.German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany;
25.UCCH, Univ Med Ctr Hamburg Eppendorf, Canc Epidemiol, D-20246 Hamburg, Germany;
26.Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98109 USA;
27.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;
28.Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England;
29.Oxford NIHR Biomed Res Ctr, Oxford OX3 7BN, England;
30.Univ Sydney, Westmead Inst Med Res, Sydney, NSW 2145, Australia;
31.Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA;
32.Alberta Hlth Serv, Dept Canc Epidemiol & Prevent Res, Calgary, AB T2N 4N2, Canada;
33.Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA;
34.Univ Sheffield, Sheffield Inst Nucle Acids SInFoNiA, Dept Oncol & Metab, Sheffield S10 2TN, S Yorkshire, England;
35.Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA 02115 USA;
36.Karolinska Inst, Dept Med Epidemiol & Biostat, S-17165 Stockholm, Sweden;
37.Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England;
38.VIB, Vesalius Res Ctr, B-3000 Leuven, Belgium;
39.Univ Leuven, Lab Translat Genet, Dept Human Genet, B-3000 Leuven, Belgium;
40.Univ Utah, Canc Res Huntsman Canc Inst, Dept Populat Hlth Sci, Salt Lake City, UT 84112 USA;
41.Hannover Med Sch, Gynaecol Res Unit, D-30625 Hannover, Germany;
42.Mayo Clin, Div Gynecol Oncol, Dept Obstet & Gynecol, Rochester, MN 55905 USA;
43.Friedrich Schiller Univ, Jena Univ Hosp, Dept Gynaecol, D-07743 Jena, Germany;
44.Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Human Genet, Comprehens Canc Ctr Erlangen EMN, D-91054 Erlangen, Germany;
45.Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol & Oncol, Dept Med, Los Angeles, CA 90095 USA;
46.Kansas Univ, Med Ctr, Dept Biostat, Kansas City, KS 66160 USA;
47.Curtin Univ, Sch Publ Hlth, Perth, WA 6102, Australia;
48.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia;
49.Inst Canc Res, Div Genet & Epidemiol, London SM2 5NG, England;
50.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA;
51.Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;
52.Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia;
53.Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN 55905 USA;
54.Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA;
55.South Gen Hosp, Dept Oncol, S-11883 Stockholm, Sweden;
56.Univ Massachusetts, Dept Biostat & Epidemiol, Amherst, MA 01003 USA;
57.Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge CB1 8RN, England;
58.St Georges Univ London, Dept Clin Genet, London SW17 0RE, England;
59.Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers, N-5020 Bergen, Norway;
60.Haukeland Hosp, Dept Gynecol & Obstet, N-5021 Bergen, Norway;
61.Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA;
62.Radiumhospitalet, Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0379 Oslo, Norway;
63.Univ Oslo, Inst Clin Med, Fac Med, N-0450 Oslo, Norway;
64.Univ Oslo, Oslo Univ Hosp, Dept Clin Mol Biol, N-0450 Oslo, Norway;
65.VIB Ctr Canc Biol, VIB, B-3001 Leuven, Belgium;
66.Univ Hawaii, Ctr Canc, Epidemiol Program, Honolulu, HI 96813 USA;
67.Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA;
68.Karolinska Inst, Dept Mol Med & Surg, S-17176 Stockholm, Sweden;
69.M Sklodowska Curie Canc Ctr Oncol Inst, Dept Canc Epidemiol & Prevent, PL-02034 Warsaw, Poland;
70.Vanderbilt Univ, Dept Med, Vanderbilt Ingram Canc Ctr, Sch Med,Div Epidemiol,Vanderbilt Epidemiol Ctr, Nashville, TN 37232 USA;
71.Yale Sch Publ Hlth, Chron Dis Epidemiol, New Haven, CT 06510 USA;
72.H Lee Moffitt Canc Ctr & Res Inst, Dept Anat Pathol, Tampa, FL 33612 USA;
73.Univ Birmingham, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England;
74.Ludwig Maximilians Univ Munchen, Dept Gynecol & Obstet, D-80336 Munich, Germany;
75.Cyprus Inst Neurol & Genet, Dept Electron Microscopy Mol Pathol, Nicosia, Cyprus;
76.Karolinska Inst, Dept Womens & Childrens Hlth, S-17176 Stockholm, Sweden;
77.Univ Calif Davis, Dept Biochem & Mol Med, Davis, CA 95817 USA;
78.Lund Univ, Dept Canc Epidemiol, Clin Sci, S-22242 Lund, Sweden;
79.Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW 2308, Australia;
80.London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England;
81.Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA;
82.Dana Farber Canc Inst, Boston, MA 02115 USA;
83.Univ Melbourne, Royal Womens Hosp, Gynaecol Res Ctr, Dept Obstet & Gynaecol, Parkville, Vic 3052, Australia;
84.Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynaecol & Obstet, D-91054 Erlangen, Germany;
85.Ctr Canc Prevent CPO Peimonte, I-10126 Turin, Italy;
86.Human Genet Fdn HuGeF, I-10126 Turin, Italy;
87.Univ Wisconsin, Sch Med & Publ Hlth, Dept Obstet & Gynecol, Madison, WI 53715 USA;
88.Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA;
89.John Hunter Hosp, Div Mol Med, Pathol North, Newcastle, NSW 2308, Australia;
90.Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic 3168, Australia;
91.Inst Canc Res, Div Breast Canc Res, London SW7 3RP, England;
92.Karolinska Inst, Clin Genet, S-17176 Stockholm, Sweden;
93.Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA;
94.Univ Hosp Leuven, Leuven Canc Inst, Div Gynecol Oncol, Dept Obstet & Gynaecol, B-3000 Leuven, Belgium;
95.QIMR Berghofer Med Res Inst, Dept Populat Hlth, Brisbane, Qld 4006, Australia;
96.Mayo Clin, Div Biomed Stat & Informat, Dept Hlth Sci Res, Rochester, MN 55905 USA;
97.Karolinska Inst, Div Nutr Epidemiol, Dept Environm Med, S-17177 Stockholm, Sweden;
98.Shanghai Jiao Tong Univ, Shanghai Canc Inst, State Key Lab Oncogene & Related Genes, Dept Epidemiol,Renji Hosp,Sch Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 O&,39;Mara, Tracy A.. Identification of nine new susceptibility loci for endometrial cancer[J]. NATURE COMMUNICATIONS,2018,9.
APA O&,&39;Mara, Tracy A..(2018).Identification of nine new susceptibility loci for endometrial cancer.NATURE COMMUNICATIONS,9.
MLA O&,et al."Identification of nine new susceptibility loci for endometrial cancer".NATURE COMMUNICATIONS 9(2018).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[O&]的文章
[39;Mara, Tracy A.]的文章
百度学术
百度学术中相似的文章
[O&]的文章
[39;Mara, Tracy A.]的文章
必应学术
必应学术中相似的文章
[O&]的文章
[39;Mara, Tracy A.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。