Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-05291-5 |
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy | |
Liu, Feng1; Chen, Jianxia1,2; Wang, Peng3,4; Li, Haohao3; Zhou, Yilong3; Liu, Haipeng1,2; Liu, Zhonghua1; Zheng, Ruijuan1; Wang, Lin3; Yang, Hua1; Cui, Zhenling1; Wang, Fei3; Huang, Xiaochen1; Wang, Jie1; Sha, Wei4; Xiao, Heping4; Ge, Baoxue1,2,3 | |
2018-10-16 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) kills millions every year, and there is urgent need to develop novel anti-TB agents due to the fast-growing of drug-resistant TB. Although autophagy regulates the intracellular survival of Mtb, the role of calcium (Ca2+) signaling in modulating autophagy during Mtb infection remains largely unknown. Here, we show that microRNA miR-27a is abundantly expressed in active TB patients, Mtb-infected mice and macrophages. The target of miR-27a is the ER-located Ca2+ transporter CAC-NA2D3. Targeting of this transporter leads to the downregulation of Ca2+ signaling, thus inhibiting autophagosome formation and promoting the intracellular survival of Mtb. Mice lacking of miR-27a and mice treated with an antagomir to miR-27a are more resistant to Mtb infection. Our findings reveal a strategy for Mtb to increase intracellular survival by manipulating the Ca2+-associated autophagy, and may also support the development of host-directed anti-TB therapeutic approaches. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447361400014 |
WOS关键词 | ANTIMICROBIAL RESPONSES ; IMMUNE-RESPONSES ; CELL-SURVIVAL ; PROTEIN ; INFECTION ; CA2+ ; MACROPHAGES ; PHARMACOLOGY ; ACTIVATION ; MECHANISM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203885 |
专题 | 资源环境科学 |
作者单位 | 1.Tongji Univ, Sch Med, Shanghai Pulm Hosp, Shanghai Key Lab TB, Shanghai 200433, Peoples R China; 2.Tongji Univ, Sch Med, Shanghai Pulm Hosp, Clin Translat Res Ctr, Shanghai 200433, Peoples R China; 3.Tongji Univ, Sch Med, Dept Microbiol & Immunol, Shanghai 200092, Peoples R China; 4.Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept TB, Shanghai 200433, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Feng,Chen, Jianxia,Wang, Peng,et al. MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Liu, Feng.,Chen, Jianxia.,Wang, Peng.,Li, Haohao.,Zhou, Yilong.,...&Ge, Baoxue.(2018).MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy.NATURE COMMUNICATIONS,9. |
MLA | Liu, Feng,et al."MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论