Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-04692-w |
Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein | |
Tian, Daiyin1,2; Battles, Michael B.3; Moin, Syed M.1; Chen, Man1; Modjarrad, Kayvon4,5; Kumar, Azad1; Kanekiyo, Masaru1; Graepel, Kevin W.6; Taher, Noor M.3; Hotard, Anne L.7,10; Moore, Martin L.7,11; Zhao, Min8,9; Zheng, Zi-Zheng8,9; Xia, Ning-Shao8,9; McLellan, Jason S.3; Graham, Barney S.1 | |
2017-11-30 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | A licensed vaccine for respiratory syncytial virus (RSV) is unavailable, and passive prophylaxis with the antibody palivizumab is restricted to high-risk infants. Recently isolated antibodies 5C4 and D25 are substantially more potent than palivizumab, and a derivative of D25 is in clinical trials. Here we show that unlike D25, 5C4 preferentially neutralizes subtype A viruses. The crystal structure of 5C4 bound to the RSV fusion (F) protein reveals that the overall binding mode of 5C4 is similar to that of D25, but their angles of approach are substantially different. Mutagenesis and virological studies demonstrate that RSV F residue 201 is largely responsible for the subtype specificity of 5C4. These results improve our understanding of subtype-specific immunity and the neutralization breadth requirements of next-generation antibodies, and thereby contribute to the design of broadly protective RSV vaccines. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000416895400019 |
WOS关键词 | REVERSE GENETICS ; INFECTION ; GENOTYPE ; PATHOGENESIS ; GENERATION ; SEVERITY ; CHILDREN ; INFANTS ; VACCINE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203843 |
专题 | 资源环境科学 |
作者单位 | 1.NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA; 2.Chongqing Med Univ, Dept Pulmonol, Childrens Hosp, Chongqing 400014, Peoples R China; 3.Geisel Sch Med Dartmouth, Dept Biochem & Cell Biol, Hanover, NH 03755 USA; 4.Walter Reed Army Inst Res, Silver Spring, MD 20910 USA; 5.Henry M Jackson Fdn, Bethesda, MD 20817 USA; 6.Vanderbilt Univ, Dept Pediat, Med Ctr, Nashville, TN 37208 USA; 7.Emory Univ, Dept Pediat, Atlanta, GA 30322 USA; 8.Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Fujian, Peoples R China; 9.Xiamen Univ, Sch Life Sci, Natl Inst Diagnost & Vaccine Dev Infect Dis, Xiamen 361005, Fujian, Peoples R China; 10.Ctr Dis Control & Prevent, Div Select Agents & Toxins, Atlanta, GA 30333 USA; 11.Meissa Vaccines Inc South, San Francisco, CA 94080 USA |
推荐引用方式 GB/T 7714 | Tian, Daiyin,Battles, Michael B.,Moin, Syed M.,et al. Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Tian, Daiyin.,Battles, Michael B..,Moin, Syed M..,Chen, Man.,Modjarrad, Kayvon.,...&Graham, Barney S..(2017).Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.NATURE COMMUNICATIONS,8. |
MLA | Tian, Daiyin,et al."Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论