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DOI | 10.1038/s41467-018-04040-y |
Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration | |
Huang, Wei1,2,3; Feng, Yuliang1,2; Liang, Jialiang3; Yu, Hao3; Wang, Cheng4,5; Wang, Boyu6; Wang, Mingyang7; Jiang, Lin3; Meng, Wei8; Cai, Wenfeng3; Medvedovic, Mario9; Chen, Jenny9; Paul, Christian3; Davidson, W. Sean3; Sadayappan, Sakthivel10; Stambrook, Peter J.11; Yu, Xi-Yong1,2; Wang, Yigang3 | |
2018-02-16 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA; Netherlands |
英文摘要 | The goal of replenishing the cardiomyocyte (CM) population using regenerative therapies following myocardial infarction (MI) is hampered by the limited regeneration capacity of adult CMs, partially due to their withdrawal from the cell cycle. Here, we show that microRNA-128 (miR-128) is upregulated in CMs during the postnatal switch from proliferation to terminal differentiation. In neonatal mice, cardiac-specific overexpression of miR-128 impairs CM proliferation and cardiac function, while miR-128 deletion extends proliferation of postnatal CMs by enhancing expression of the chromatin modifier SUZ12, which suppresses p27 (cyclin-dependent kinase inhibitor) expression and activates the positive cell cycle regulators Cyclin E and CDK2. Furthermore, deletion of miR-128 promotes cell cycle re-entry of adult CMs, thereby reducing the levels of fibrosis, and attenuating cardiac dysfunction in response to MI. These results suggest that miR-128 serves as a critical regulator of endogenous CM proliferation, and might be a novel therapeutic target for heart repair. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000425286700002 |
WOS关键词 | MYOCYTE CELL-CYCLE ; ZEBRAFISH HEART ; MICE LACKING ; HYPERPLASIA ; EXPRESSION ; ERBB2 ; DIFFERENTIATION ; ACTIVATION ; P27(KIP1) ; NETWORKS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203794 |
专题 | 资源环境科学 |
作者单位 | 1.Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China; 2.Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China; 3.Univ Cincinnati, Coll Med, Dept Pathol & Lab Med, Cincinnati, OH 45267 USA; 4.Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Dept Mol Biol, NL-6525 Gelderland, Netherlands; 5.Radboud Univ Nijmegen, Fac Sci, NL-6525 Gelderland, Netherlands; 6.Samaritan Med Ctr, 830 Washington St, Watertown, NY 13601 USA; 7.Univ Cincinnati, Coll Engn & Appl Sci, Cincinnati, OH 45221 USA; 8.Sun Yat Sen Univ, Affiliated Hosp 3, Div Liver Surg, Guangzhou 510630, Guangdong, Peoples R China; 9.Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA; 10.Univ Cincinnati, Coll Med, Heart Lung & Vasc Inst, Div Cardiovasc Hlth & Dis,Dept Internal Med, Cincinnati, OH 45267 USA; 11.Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA |
推荐引用方式 GB/T 7714 | Huang, Wei,Feng, Yuliang,Liang, Jialiang,et al. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Huang, Wei.,Feng, Yuliang.,Liang, Jialiang.,Yu, Hao.,Wang, Cheng.,...&Wang, Yigang.(2018).Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.NATURE COMMUNICATIONS,9. |
MLA | Huang, Wei,et al."Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration".NATURE COMMUNICATIONS 9(2018). |
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