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DOI | 10.1038/s41467-018-03809-5 |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters | |
de Lorgeril, Julien1; Lucasson, Aude1; Petton, Bruno2; Toulza, Eve1; Montagnani, Caroline1; Clerissi, Camille1; Vidal-Dupiol, Jeremie1; Chaparro, Cristian1; Galinier, Richard1; Escoubas, Jean-Michel1; Haffner, Philippe1; Degremont, Lionel3; Charriere, Guillaume M.1; Lafont, Maxime1; Delort, Abigail1; Vergnes, Agnes1; Chiarello, Marlene4; Faury, Nicole3; Rubio, Tristan1; Leroy, Marc A.1; Perignon, Adeline5; Regler, Denis5; Morga, Benjamin3; Alunno-Bruscia, Marianne2; Boudry, Pierre6; Le Roux, Frederique7; Destoumieux-Garzon, Delphine1; Gueguen, Yannick1; Mitta, Guillaume1 | |
2018-10-11 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 mu Var. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447075700003 |
WOS关键词 | CRASSOSTREA-GIGAS ; OSTREID HERPESVIRUS-1 ; ANTIVIRAL RESPONSE ; READ ALIGNMENT ; HERPES-VIRUS ; MU-VAR ; MORTALITY ; TEMPERATURE ; FRANCE ; IRELAND |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203784 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Perpignan, Univ Montpellier, IFREMER, IHPE,CNRS, Via Domitia,Pl E Bataillon, F-34095 Montpellier, France; 2.UBO, CNRS, IRD, LEMAR UMR 6539,Ifremer, 11 Presquile Vivier, F-29840 Argenton En Landunvez, France; 3.IFREMER, Lab Genet & Pathol Mollusques Marins, Ave Mus de Loup, F-17930 La Tremblade, France; 4.Univ Montpellier, CNRS, IFREMER, Marine Biodivers Exploitat & Conservat MARBEC,IR, Pl E Bataillon, F-34095 Montpellier, France; 5.CRCM, Com Conchyliculture Mediterranee, F-34140 Meze, France; 6.UBO, IRD, IFREMER, LEMAR UMR6539,CNRS, ZI Pointe Diable,CS 10070, F-29280 Plouzane, France; 7.UPMC Paris 06, Sorbonne Univ, CNRS, UMR 8227,LBI2M,Ifremer,Stn Biol Roscoff, CS 90074, F-29680 Roscoff, France |
推荐引用方式 GB/T 7714 | de Lorgeril, Julien,Lucasson, Aude,Petton, Bruno,et al. Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters[J]. NATURE COMMUNICATIONS,2018,9. |
APA | de Lorgeril, Julien.,Lucasson, Aude.,Petton, Bruno.,Toulza, Eve.,Montagnani, Caroline.,...&Mitta, Guillaume.(2018).Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters.NATURE COMMUNICATIONS,9. |
MLA | de Lorgeril, Julien,et al."Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters".NATURE COMMUNICATIONS 9(2018). |
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