Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-03808-6 |
SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression | |
Vazquez, M. J.1,2,3,4; Toro, C. A.4; Castellano, J. M.1,2,3,4; Ruiz-Pino, F.1,2,3,4; Roa, J.1,2,3,4; Beiroa, D.6,7; Heras, V1,2,3; Velasco, I1,2,3,4; Dieguez, C.4,6,7; Pinilla, L.1,2,3,4; Gaytan, F.1,2; Nogueiras, R.4,6,7; Bosch, M. A.8; Ronnekleiv, O. K.8,9; Lomniczi, A.5; Ojeda, S. R.9; Tena-Sempere, M.1,2,3,4,10 | |
2018-10-10 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; USA; Finland |
英文摘要 | Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are unknown. Here, we identify Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that restrains female puberty via epigenetic repression of the puberty-activating gene, Kiss1. SIRT1 is expressed in hypothalamic Kiss1 neurons and suppresses Kiss1 expression. SIRT1 interacts with the Polycomb silencing complex to decrease Kiss1 promoter activity. As puberty approaches, SIRT1 is evicted from the Kiss1 promoter facilitating a repressive-to-permissive switch in chromatin landscape. Early-onset overnutrition accelerates these changes, enhances Kiss1 expression and advances puberty. In contrast, undernutrition raises SIRT1 levels, protracts Kiss1 repression and delays puberty. This delay is mimicked by central pharmacological activation of SIRT1 or SIRT1 overexpression, achieved via transgenesis or virogenetic targeting to the ARC. Our results identify SIRT1-mediated inhibition of Kiss1 as key epigenetic mechanism by which nutritional cues and obesity influence mammalian puberty. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446846600013 |
WOS关键词 | ARCUATE NUCLEUS ; FEMALE PUBERTY ; HYPOGONADOTROPIC HYPOGONADISM ; CALORIE RESTRICTION ; HISTONE DEACETYLASE ; HORMONE SECRETION ; REPRODUCTIVE AXIS ; GENE-EXPRESSION ; NEUROKININ B ; LIFE-SPAN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203771 |
专题 | 资源环境科学 |
作者单位 | 1.Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba 14004, Spain; 2.Univ Cordoba, Dept Cell Biol Physiol & Immunol, E-14004 Cordoba, Spain; 3.Hosp Univ Reina Sofia, Cordoba 14004, Spain; 4.Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Cordoba 14004, Spain; 5.Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Genet, Beaverton, OR 97006 USA; 6.Univ Santiago de Compostela, Inst Invest Sanitaria, Fac Med, Dept Physiol, Santiago De Compostela 15782, Spain; 7.Univ Santiago de Compostela, Inst Invest Sanitaria, CIMUS, Santiago De Compostela 15782, Spain; 8.Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97239 USA; 9.Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Neurosci, Beaverton, OR 97006 USA; 10.Univ Turku, FiDiPro Program, Turku 20014, Finland |
推荐引用方式 GB/T 7714 | Vazquez, M. J.,Toro, C. A.,Castellano, J. M.,et al. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Vazquez, M. J..,Toro, C. A..,Castellano, J. M..,Ruiz-Pino, F..,Roa, J..,...&Tena-Sempere, M..(2018).SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.NATURE COMMUNICATIONS,9. |
MLA | Vazquez, M. J.,et al."SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression".NATURE COMMUNICATIONS 9(2018). |
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