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DOI | 10.1038/s41467-018-03564-7 |
Nanoparticle elasticity directs tumor uptake | |
Guo, Peng1,2,3,4; Liu, Daxing4,6; Subramanyam, Kriti1,5,7; Wang, Biran4,8; Yang, Jiang1,2,3; Huang, Jing1,2,3; Auguste, Debra T.4,6; Moses, Marsha A.1,2,3 | |
2018-01-09 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | To date, the role of elasticity in drug delivery remains elusive due to the inability to measure microscale mechanics and alter rheology without affecting chemistry. Herein, we describe the in vitro cellular uptake and in vivo tumor uptake of nanolipogels (NLGs). NLGs are composed of identical lipid bilayers encapsulating an alginate core, with tunable elasticity. The elasticity of NLGs was evaluated by atomic force microscopy, which demonstrated that they exhibit Young's moduli ranging from 45 +/- 9 to 19,000 +/- 5 kPa. Neoplastic and non-neoplastic cells exhibited significantly greater uptake of soft NLGs (Young's modulus <1.6 MPa) relative to their elastic counterparts (Young's modulus >13.8 MPa). In an orthotopic breast tumor model, soft NLGs accumulated significantly more in tumors, whereas elastic NLGs preferentially accumulated in the liver. Our findings demonstrate that particle elasticity directs tumor accumulation, suggesting that it may be a design parameter to enhance tumor delivery efficiency. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000419658100029 |
WOS关键词 | MEMBRANE-FUSION ; BREAST-CANCER ; DRUG-DELIVERY ; PARTICLES ; SHAPE ; ACCUMULATION ; PHAGOCYTOSIS ; CIRCULATION ; CLEARANCE ; STIFFNESS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203767 |
专题 | 资源环境科学 |
作者单位 | 1.Boston Childrens Hosp, Vasc Biol Program, 300 Longwood Ave, Boston, MA 02115 USA; 2.Harvard Med Sch, Dept Surg, 300 Longwood Ave, Boston, MA 02115 USA; 3.Boston Childrens Hosp, 300 Longwood Ave, Boston, MA 02115 USA; 4.CUNY, Dept Biomed Engn, 160 Convent Ave, New York, NY 10031 USA; 5.Harvard Univ, Sch Engn & Appl Sci, 29 Oxford St, Boston, MA 02115 USA; 6.Northeastern Univ, Dept Chem Engn, 360 Huntington Ave, Boston, MA 02115 USA; 7.MIT, Harvard Mit Div Hlth Sci & Technol, 500 Main St, Cambridge, MA 02139 USA; 8.Texas A&M Univ, Dept Ind & Syst Engn, 101 Bizzell St, College Stn, TX 77843 USA |
推荐引用方式 GB/T 7714 | Guo, Peng,Liu, Daxing,Subramanyam, Kriti,et al. Nanoparticle elasticity directs tumor uptake[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Guo, Peng.,Liu, Daxing.,Subramanyam, Kriti.,Wang, Biran.,Yang, Jiang.,...&Moses, Marsha A..(2018).Nanoparticle elasticity directs tumor uptake.NATURE COMMUNICATIONS,9. |
MLA | Guo, Peng,et al."Nanoparticle elasticity directs tumor uptake".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
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