Cancer cells with trapped nuclei cut their way through the extracellular matrix

doi:10.1038/s41467-018-03698-8

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-018-03698-8
	Cancer cells with trapped nuclei cut their way through the extracellular matrix
	Dornier, Emmanuel 1; Norman, Jim C.1,2
	2018-09-27
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2018
卷号	9
文章类型	Article
语种	英语
国家	Scotland
英文摘要	When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension is sensed by a nucleus-centrosome connection that activates trafficking of endosomal vesicles containing the matrix metalloprotease, MT1-MMP1 to the site of constraint. Recent evidence shows how focussed ECM degradation relieves the constraint and allows cancer cells to continue invading.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000445819400005
WOS关键词	MIGRATION ; INVASION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203748
专题	资源环境科学
作者单位	1.CRUK Beatson Inst Canc Res, Garscube Estate, Glasgow G61 1BD, Lanark, Scotland; 2.Univ Glasgow, Inst Canc Sci, Glasgow G61 1QH, Lanark, Scotland
推荐引用方式 GB/T 7714	Dornier, Emmanuel,Norman, Jim C.. Cancer cells with trapped nuclei cut their way through the extracellular matrix[J]. NATURE COMMUNICATIONS,2018,9.
APA	Dornier, Emmanuel,&Norman, Jim C..(2018).Cancer cells with trapped nuclei cut their way through the extracellular matrix.NATURE COMMUNICATIONS,9.
MLA	Dornier, Emmanuel,et al."Cancer cells with trapped nuclei cut their way through the extracellular matrix".NATURE COMMUNICATIONS 9(2018).