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DOI | 10.1038/s41467-018-03508-1 |
Optical trapping of otoliths drives vestibular behaviours in larval zebrafish | |
Favre-Bulle, Itia A.1,2; Stilgoe, Alexander B.1; Rubinsztein-Dunlop, Halina1; Scott, Ethan K.2,3 | |
2017-09-20 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Australia |
英文摘要 | The vestibular system, which detects gravity and motion, is crucial to survival, but the neural circuits processing vestibular information remain incompletely characterised. In part, this is because the movement needed to stimulate the vestibular system hampers traditional neuroscientific methods. Optical trapping uses focussed light to apply forces to targeted objects, typically ranging from nanometres to a few microns across. In principle, optical trapping of the otoliths (ear stones) could produce fictive vestibular stimuli in a stationary animal. Here we use optical trapping in vivo to manipulate 55-micron otoliths in larval zebrafish. Medial and lateral forces on the otoliths result in complementary corrective tail movements, and lateral forces on either otolith are sufficient to cause a rolling correction in both eyes. This confirms that optical trapping is sufficiently powerful and precise to move large objects in vivo, and sets the stage for the functional mapping of the resulting vestibular processing. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411317800006 |
WOS关键词 | MANIPULATION ; MOVEMENT ; NUCLEUS ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203734 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Queensland, Sch Math & Phys, St Lucia, Qld 4072, Australia; 2.Univ Queensland, Sch Biomed Sci, St Lucia, Qld 4072, Australia; 3.Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia |
推荐引用方式 GB/T 7714 | Favre-Bulle, Itia A.,Stilgoe, Alexander B.,Rubinsztein-Dunlop, Halina,et al. Optical trapping of otoliths drives vestibular behaviours in larval zebrafish[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Favre-Bulle, Itia A.,Stilgoe, Alexander B.,Rubinsztein-Dunlop, Halina,&Scott, Ethan K..(2017).Optical trapping of otoliths drives vestibular behaviours in larval zebrafish.NATURE COMMUNICATIONS,8. |
MLA | Favre-Bulle, Itia A.,et al."Optical trapping of otoliths drives vestibular behaviours in larval zebrafish".NATURE COMMUNICATIONS 8(2017). |
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