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DOI | 10.1038/s41467-018-03366-x |
Time units for learning involving maintenance of system-wide cFos expression in neuronal assemblies | |
Chowdhury, Ananya1,2,3,4,5,6,7; Caroni, Pico1 | |
2018-10-08 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; USA |
英文摘要 | Repeated experiences may be integrated in succession during a learning process, or they may be combined as a whole within dedicated time windows to possibly promote quality control. Here we show that in Pavlovian, incremental and incidental learning, related information acquired within time windows of 5 h is combined to determine what mice learn. Trials required for learning had to occur within 5 h, when learning-related shared cues could produce association and interference. Upon acquisition, cFos expression was elevated during 5 h throughout specific system-wide neuronal assemblies. Time window function depended on network activity and cFos expression. Local cFos activity was required for distant assembly recruitment through network activity and distant BDNF. Activation of learning-related cFos assemblies was sufficient and necessary for time window function. Therefore, learning processes consist of dedicated 5 h time windows (time units for learning), involving maintenance of system-wide neuronal assemblies through network activity and cFos expression. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446566000008 |
WOS关键词 | C-FOS ; PROTEIN-SYNTHESIS ; HIPPOCAMPAL ; PLASTICITY ; MECHANISMS ; TRANSIENT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203712 |
专题 | 资源环境科学 |
作者单位 | 1.Friedrich Miescher Inst, Maulbeerstr 66, CH-4058 Basel, Switzerland; 2.Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA; 3.Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA; 4.Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA; 5.Univ Calif Los Angeles, Dept Biobehav Sci, Los Angeles, CA 90095 USA; 6.Univ Calif Los Angeles, Integrat Ctr Learning & Memory, Los Angeles, CA 90095 USA; 7.Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA |
推荐引用方式 GB/T 7714 | Chowdhury, Ananya,Caroni, Pico. Time units for learning involving maintenance of system-wide cFos expression in neuronal assemblies[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Chowdhury, Ananya,&Caroni, Pico.(2018).Time units for learning involving maintenance of system-wide cFos expression in neuronal assemblies.NATURE COMMUNICATIONS,9. |
MLA | Chowdhury, Ananya,et al."Time units for learning involving maintenance of system-wide cFos expression in neuronal assemblies".NATURE COMMUNICATIONS 9(2018). |
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