Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-03464-w |
Raptor regulates functional maturation of murine beta cells | |
Ni, Qicheng1; Gu, Yanyun1; Xie, Yun1; Yin, Qinglei1; Zhang, Hongli1; Nie, Aifang1; Li, Wenyi1; Wang, Yanqiu1; Ning, Guang1; Wang, Weiqing1; Wang, Qidi1,2 | |
2017-06-09 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Diabetes is associated with beta cell mass loss and islet dysfunctions. mTORC1 regulates beta cell survival, proliferation and function in physiological and pathological conditions, such as pregnancy and pancreatectomy. Here we show that deletion of Raptor, which is an essential component of mTORC1, in insulin-expressing cells promotes hypoinsulinemia and glucose intolerance. Raptor-deficient beta cells display reduced glucose responsiveness and exhibit a glucose metabolic profile resembling fetal beta cells. Knockout islets have decreased expression of key factors of functional maturation and upregulation of neonatal markers and beta cell disallowed genes, resulting in loss of functional maturity. Mechanistically, Raptor-deficient beta cells show reduced expression of DNA-methyltransferase 3a and altered patterns of DNA methylation at loci that are involved in the repression of disallowed genes. The present findings highlight a novel role of mTORC1 as a core mechanism governing postnatal beta cell maturation and physiologic beta cell mass during adulthood. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402964400002 |
WOS关键词 | INDUCED INSULIN-SECRETION ; MESSENGER-RNA TRANSLATION ; LACTATE-DEHYDROGENASE ; ENDOCRINE PANCREAS ; GLUCOSE-TOLERANCE ; MAMMALIAN TARGET ; HEXOKINASE-I ; RAPAMYCIN ; MICE ; MTOR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203707 |
专题 | 资源环境科学 |
作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, Key Lab Endocrine & Metab Dis, Chinese Hlth Minist,Ruijin Hosp, Shanghai 200025, Peoples R China; 2.Shanghai Jiao Tong Univ, Sino French Res Ctr Life Sci & Genom, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China |
推荐引用方式 GB/T 7714 | Ni, Qicheng,Gu, Yanyun,Xie, Yun,et al. Raptor regulates functional maturation of murine beta cells[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Ni, Qicheng.,Gu, Yanyun.,Xie, Yun.,Yin, Qinglei.,Zhang, Hongli.,...&Wang, Qidi.(2017).Raptor regulates functional maturation of murine beta cells.NATURE COMMUNICATIONS,8. |
MLA | Ni, Qicheng,et al."Raptor regulates functional maturation of murine beta cells".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论