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DOI | 10.1038/s41467-018-03376-9 |
Pregnancy duration and breast cancer risk | |
Husby, Anders1,2; Wohlfahrt, Jan1; Oyen, Nina1,3,4; Melbye, Mads1,5,6 | |
2018-10-23 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Denmark; USA; Norway |
英文摘要 | Full-term pregnancies reduce a woman's long-term breast cancer risk, while abortions have been shown to have no effect. The precise minimal duration of pregnancy necessary to lower a woman's breast cancer risk is, however, unknown. Here we provide evidence which point to the protective effect of pregnancy on breast cancer risk arising precisely at the 34th pregnancy week. Using a cohort of 2.3 million Danish women, we found the reduction in breast cancer risk was not observed for pregnancies lasting 33 weeks or less, but restricted to those pregnancies lasting 34 weeks or longer. We further found that parity, socioeconomic status, and vital status of the child at birth did not explain the association, and also replicated our finding in data from 1.6 million women in Norway. We suggest that a distinct biological effect introduced around week 34 of pregnancy holds the key to understand pregnancy-associated breast cancer protection. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000448042300001 |
WOS关键词 | COLLABORATIVE REANALYSIS ; PRETERM DELIVERY ; ALCOHOL-CONSUMPTION ; INDIVIDUAL DATA ; MAMMARY-GLAND ; MATERNAL RISK ; FULL-TERM ; BIRTH ; WOMEN ; AGE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203694 |
专题 | 资源环境科学 |
作者单位 | 1.Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark; 2.Stanford Univ, Dept Biomed Data Sci, Sch Med, Stanford, CA 94305 USA; 3.Univ Bergen, Fac Med, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway; 4.Haukeland Hosp, Dept Med Genet, N-5021 Bergen, Norway; 5.Univ Copenhagen, Dept Clin Med, DK-2100 Copenhagen, Denmark; 6.Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Husby, Anders,Wohlfahrt, Jan,Oyen, Nina,et al. Pregnancy duration and breast cancer risk[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Husby, Anders,Wohlfahrt, Jan,Oyen, Nina,&Melbye, Mads.(2018).Pregnancy duration and breast cancer risk.NATURE COMMUNICATIONS,9. |
MLA | Husby, Anders,et al."Pregnancy duration and breast cancer risk".NATURE COMMUNICATIONS 9(2018). |
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