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DOI | 10.1038/s41467-018-03187-y |
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation | |
Du, Meng1,2; Yuan, Lin1,2; Tan, Xin1,2; Huang, Dandan1,2; Wang, Xiaojing3; Zheng, Zhe1,2; Mao, Xiaoxiang1,2; Li, Xiangrao1,2; Yang, Liu1,2; Huang, Kun1,2; Zhang, Fengxiao1,2; Wang, Yan1,2; Luo, Xi1,2; Huang, Dan1,2; Huang, Kai1,2 | |
2017-12-11 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRR) with a crucial function in innate immune responses. Activation of TLR4 signaling at the plasma membrane by lipopolysaccharide (LPS) stimulates proinflammatory signaling pathways dependent on the E3 ubiquitin ligase TRAF6. Here we show the LPS-induced long non-coding RNA (lncRNA) Mirt2 functions as a checkpoint to prevent aberrant activation of inflammation, and is a potential regulator of macrophage polarization. Mirt2 associates with, and attenuates Lys63 (K63)-linked ubiquitination of, TRAF6, thus inhibiting activation of NF-kappa B and MAPK pathways and limiting production of proinflammatory cytokines. Adenovirus mediated gene transfer of Mirt2 protects mice from endotoxemia induced fatality and multi-organ dysfunction. These findings identify lncRNA Mirt2 as a negative feedback regulator of excessive inflammation. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000417649500025 |
WOS关键词 | LONG NONCODING RNA ; TOLL-LIKE RECEPTOR ; IMMUNE-RESPONSES ; ACTIVATION ; UBIQUITIN ; KINASE ; TRAF6 ; POLARIZATION ; DOMAIN ; LIPOPOLYSACCHARIDE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203679 |
专题 | 资源环境科学 |
作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Cardiol, Wuhan 430000, Hubei, Peoples R China; 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Clin Ctr Human Gene Res, Wuhan 430000, Hubei, Peoples R China; 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Pediat Surg, Wuhan 430000, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Du, Meng,Yuan, Lin,Tan, Xin,et al. The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Du, Meng.,Yuan, Lin.,Tan, Xin.,Huang, Dandan.,Wang, Xiaojing.,...&Huang, Kai.(2017).The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation.NATURE COMMUNICATIONS,8. |
MLA | Du, Meng,et al."The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation".NATURE COMMUNICATIONS 8(2017). |
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