Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-02985-8 |
Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors | |
Jendzjowsky, Nicholas G.1; Roy, Arijit1; Barioni, Nicole O.1; Kelly, Margaret M.2,3; Green, Francis H. Y.2,3; Wyatt, Christopher N.4; Pye, Richard L.4; Tenorio-Lopes, Luana1; Wilson, Richard J. A.1 | |
2018-10-02 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; USA |
英文摘要 | Asthma accounts for 380,000 deaths a year. Carotid body denervation has been shown to have a profound effect on airway hyper-responsiveness in animal models but a mechanistic explanation is lacking. Here we demonstrate, using a rat model of asthma (OVA-sensitized), that carotid body activation during airborne allergic provocation is caused by systemic release of lysophosphatidic acid (LPA). Carotid body activation by LPA involves TRPV1 and LPA-specific receptors, and induces parasympathetic (vagal) activity. We demonstrate that this activation is sufficient to cause acute bronchoconstriction. Moreover, we show that prophylactic administration of TRPV1 (AMG9810) and LPA (BrP-LPA) receptor antagonists prevents bradykinin-induced asthmatic bronchoconstriction and, if administered following allergen exposure, reduces the associated respiratory distress. Our discovery provides mechanistic insight into the critical roles of carotid body LPA receptors in allergen-induced respiratory distress and suggests alternate treatment options for asthma. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446016400008 |
WOS关键词 | AIRWAY SMOOTH-MUSCLE ; BROWN-NORWAY RATS ; ALLERGEN CHALLENGE ; BRONCHOALVEOLAR LAVAGE ; INTERMITTENT HYPOXIA ; INDUCED BRONCHOCONSTRICTION ; AFFERENT ACTIVITY ; GUINEA-PIGS ; BRAIN-STEM ; INFLAMMATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203671 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calgary, Dept Physiol & Pharmacol, Hotchkiss Brain Inst, Alberta Childrens Hosp Res Inst,Cumming Sch Med, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada; 2.Univ Calgary, Dept Physiol & Pharmacol, Snyder Inst Chron Dis, Cumming Sch Med, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada; 3.Univ Calgary, Dept Pathol & Lab Med, Snyder Inst Chron Dis, Cumming Sch Med, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada; 4.Wright State Univ, Dept Neurosci Cell Biol & Physiol, 3640 Colonel Glenn Hwy, Dayton, OH 45435 USA |
推荐引用方式 GB/T 7714 | Jendzjowsky, Nicholas G.,Roy, Arijit,Barioni, Nicole O.,et al. Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Jendzjowsky, Nicholas G..,Roy, Arijit.,Barioni, Nicole O..,Kelly, Margaret M..,Green, Francis H. Y..,...&Wilson, Richard J. A..(2018).Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors.NATURE COMMUNICATIONS,9. |
MLA | Jendzjowsky, Nicholas G.,et al."Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论