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DOI | 10.1038/s41467-018-03039-9 |
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis | |
Moretti, Silvia1; Renga, Giorgia1; Oikonomou, Vasilis1; Galosi, Claudia1; Pariano, Marilena1; Iannitti, Rossana G.1; Borghi, Monica1; Puccetti, Matteo1; De Zuani, Marco2; Pucillo, Carlo E.2; Paolicelli, Giuseppe1; Zelante, Teresa1; Renauld, Jean-Christophe3; Bereshchenko, Oxana4; Sportoletti, Paolo5; Lucidi, Vincenzina6; Russo, Maria Chiara7; Colombo, Carla7; Fiscarelli, Ersilia8; Lass-Floerl, Cornelia9; Majo, Fabio6; Ricciotti, Gabriella8; Ellemunter, Helmut10; Ratclif, Luigi11; Talesa, Vincenzo Nicola1; Napolioni, Valerio1; Romani, Luigina1 | |
2017-01-16 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Italy; Belgium; Austria |
英文摘要 | T helper 9 (Th9) cells contribute to lung inflammation and allergy as sources of interleukin-9 (IL-9). However, the mechanisms by which IL-9/Th9 mediate immunopathology in the lung are unknown. Here we report an IL-9-driven positive feedback loop that reinforces allergic inflammation. We show that IL-9 increases IL-2 production by mast cells, which leads to expansion of CD25(+) type 2 innate lymphoid cells (ILC2) and subsequent activation of Th9 cells. Blocking IL-9 or inhibiting CD117 (c-Kit) signalling counteracts the pathogenic effect of the described IL-9-mast cell-IL-2 signalling axis. Overproduction of IL-9 is observed in expectorates from cystic fibrosis (CF) patients, and a sex-specific variant of IL-9 is predictive of allergic reactions in female patients. Our results suggest that blocking IL-9 may be a therapeutic strategy to ameliorate inflammation associated with microbial colonization in the lung, and offers a plausible explanation for gender differences in clinical outcomes of patients with CF. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000391869700002 |
WOS关键词 | INNATE LYMPHOID-CELLS ; TGF-BETA ; IL-33 ; EXPRESSION ; INDUCTION ; CYTOKINE ; INFILTRATION ; ACTIVATION ; INFECTION ; RESPONSES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203659 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Perugia, Dept Expt Med, I-06132 Perugia, Italy; 2.Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy; 3.Ludwig Inst Canc Res, Brussels Branch, B-1200 Brussels, Belgium; 4.Univ Perugia, Pharmacol Sect, Dept Med, I-06132 Perugia, Italy; 5.Osped S Maria Misericordia, Inst Haematol, CREO Ctr Ric Ematooncol, I-06132 Perugia, Italy; 6.Gesu Childrens Hosp, Unit Endocrinol & Diabet, I-00165 Rome, Italy; 7.Univ Milan, Osped Maggiore Policlin, Fdn IRCCS Ca Granda, I-20122 Milan, Italy; 8.Bambino Gesu Childrens Hosp IRCCS, I-00165 Rome, Italy; 9.Med Univ Innsbruck, Div Hyg & Med Microbiol, A-6020 Innsbruck, Austria; 10.Med Univ Innsbruck, CF Ctr, A-6020 Innsbruck, Austria; 11.Ist Osped G Tatarella, Serv Supporto Fibrosi Cist, I-71042 Foggia, Cerignola, Italy |
推荐引用方式 GB/T 7714 | Moretti, Silvia,Renga, Giorgia,Oikonomou, Vasilis,et al. A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Moretti, Silvia.,Renga, Giorgia.,Oikonomou, Vasilis.,Galosi, Claudia.,Pariano, Marilena.,...&Romani, Luigina.(2017).A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis.NATURE COMMUNICATIONS,8. |
MLA | Moretti, Silvia,et al."A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis".NATURE COMMUNICATIONS 8(2017). |
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