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DOI | 10.1038/s41467-018-03043-z |
Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing | |
Xie, Qing1; Liu, Yueli1; Cai, Tao2; Horton, Corrigan1; Stefanson, Joshua1; Wang, Zhu A.1 | |
2017-01-23 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Androgen signals through androgen receptor (AR) to influence prostate development and cancer. How stromal and epithelial AR regulate prostate homeostasis remains unclear. Using genetic lineage tracing, we systematically investigated the role of cell-autonomous AR in different prostate epithelial cell types. Here we show that AR is dispensable for basal cell maintenance, but is cell-autonomously required for the luminal differentiation of rare basal stem cells. In contrast, AR deletion in luminal cells alters cell morphology and induces transient over-proliferation, without affecting androgen-mediated luminal cell survival or regeneration. However, AR is selectively required for the maintenance of daughter cells produced by castration-resistant Nkx3.1-expressing luminal stem cells (CARNs). Notably, Pten loss can override AR-loss effects in both basal and luminal compartments to initiate tumours. Our data reveal distinct cell-type-specific roles of epithelial AR in orchestrating prostate homeostasis, and question the notion that epithelial AR serves as a tumour suppressor in early cancer initiation. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000392406700001 |
WOS关键词 | TUMOR-SUPPRESSOR GENE ; STEM-CELLS ; MICE LACKING ; EPITHELIAL DEVELOPMENT ; ORGANOID CULTURES ; PROGENITOR CELLS ; MOUSE PROSTATE ; LUMINAL CELLS ; BASAL-CELLS ; CANCER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203658 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA; 2.Natl Inst Biol Sci, Sequencing Ctr, Beijing 102206, Peoples R China |
推荐引用方式 GB/T 7714 | Xie, Qing,Liu, Yueli,Cai, Tao,et al. Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Xie, Qing,Liu, Yueli,Cai, Tao,Horton, Corrigan,Stefanson, Joshua,&Wang, Zhu A..(2017).Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing.NATURE COMMUNICATIONS,8. |
MLA | Xie, Qing,et al."Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing".NATURE COMMUNICATIONS 8(2017). |
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