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DOI | 10.1038/s41467-017-02342-1 |
The hydrolase LpqI primes mycobacterial peptidoglycan recycling | |
Moynihan, Patrick J.1; Cadby, Ian T.1; Veerapen, Natacha1; Jankute, Monika1; Crosatti, Marialuisa2; Mukamolova, Galina, V2; Lovering, Andrew L.1; Besra, Gurdyal S.1 | |
2019-06-14 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Growth and division by most bacteria requires remodelling and cleavage of their cell wall. A byproduct of this process is the generation of free peptidoglycan (PG) fragments known as muropeptides, which are recycled in many model organisms. Bacteria and hosts can harness the unique nature of muropeptides as a signal for cell wall damage and infection, respectively. Despite this critical role for muropeptides, it has long been thought that pathogenic mycobacteria such as Mycobacterium tuberculosis do not recycle their PG. Herein we show that M. tuberculosis and Mycobacterium bovis BCG are able to recycle components of their PG. We demonstrate that the core mycobacterial gene lpqI, encodes an authentic NagZ beta-N-acetylglucosaminidase and that it is essential for PG-derived amino sugar recycling via an unusual pathway. Together these data provide a critical first step in understanding how mycobacteria recycle their peptidoglycan. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000471586800003 |
WOS关键词 | BETA-N-ACETYLGLUCOSAMINIDASE ; CELL-WALL ; NAGZ ; TUBERCULOSIS ; GENE ; IDENTIFICATION ; ENZYMES ; SYSTEM ; MUREIN ; STRESS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203641 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Birmingham, Inst Microbiol & Infect, Sch Biol Sci, Birmingham B15 2TT, W Midlands, England; 2.Univ Leicester, Leicester TB Res Grp, Dept Resp Sci, Leicester LE1 9HN, Leics, England |
推荐引用方式 GB/T 7714 | Moynihan, Patrick J.,Cadby, Ian T.,Veerapen, Natacha,et al. The hydrolase LpqI primes mycobacterial peptidoglycan recycling[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Moynihan, Patrick J..,Cadby, Ian T..,Veerapen, Natacha.,Jankute, Monika.,Crosatti, Marialuisa.,...&Besra, Gurdyal S..(2019).The hydrolase LpqI primes mycobacterial peptidoglycan recycling.NATURE COMMUNICATIONS,10. |
MLA | Moynihan, Patrick J.,et al."The hydrolase LpqI primes mycobacterial peptidoglycan recycling".NATURE COMMUNICATIONS 10(2019). |
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