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DOI | 10.1038/s41467-017-02691-x |
GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits | |
Pazoki, Raha1; Evangelou, Evangelos1,2; Mosen-Ansorena, David1; Pinto, Rui Climaco1,3; Karaman, Ibrahim1,3; Blakeley, Paul1,4; Gill, Dipender1,5; Zuber, Verena1; Elliott, Paul1,3,6,7; Tzoulaki, Ioanna1,2,3; Dehghan, Abbas1,3 | |
2019-08-13 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Greece |
英文摘要 | Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over-represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000480519600006 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; LD SCORE REGRESSION ; BLOOD-PRESSURE ; MENDELIAN RANDOMIZATION ; SERUM SODIUM ; GENOTYPE ; INSULIN ; BIAS ; POLYMORPHISMS ; CONSUMPTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203631 |
专题 | 资源环境科学 |
作者单位 | 1.MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus,Norfolk Pl, London W2 1PG, England; 2.Univ Ioannina, Med Sch, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece; 3.Imperial Coll London, Dementia Res Inst, London W2 1PG, England; 4.Imperial Coll London, NIHR Imperial Biomed Res Ctr, ITMAT Data Sci Grp, London W2 1PG, England; 5.Imperial Coll London, Dept Stroke Med, London W2 1PG, England; 6.Imperial Coll, NIHR Biomed Res Ctr, London W2 1NY, England; 7.Hlth Data Res UK London, London NW1 2BE, England |
推荐引用方式 GB/T 7714 | Pazoki, Raha,Evangelou, Evangelos,Mosen-Ansorena, David,et al. GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Pazoki, Raha.,Evangelou, Evangelos.,Mosen-Ansorena, David.,Pinto, Rui Climaco.,Karaman, Ibrahim.,...&Dehghan, Abbas.(2019).GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits.NATURE COMMUNICATIONS,10. |
MLA | Pazoki, Raha,et al."GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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