Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-017-02412-4 |
Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming | |
Bloom, Amanda L. M.1; Jin, Richard M.1; Leipheimer, Jay1; Bard, Jonathan E.2; Yergeau, Donald2; Wohlfert, Elizabeth A.1; Panepinto, John C.1 | |
2019-10-30 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | A common feature shared by systemic fungal pathogens of environmental origin, such as Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In C. neoformans, this adaptation is accompanied by Ccr4-mediated decay of ribosomal protein mRNAs. Here we use the related, but thermo-intolerant species Cryptococcus amylolentus to demonstrate that this response contributes to host-temperature adaptation and pathogenicity of cryptococci. In a C. neoformans ccr4 Delta mutant, stabilized ribosomal protein mRNAs are retained in the translating pool, and stress-induced transcriptomic changes are reduced in comparison with the wild type strain, likely due to ineffective translation of transcription factors. In addition, the mutant displays increased exposure of cell wall glucans, and recognition by Dectin-1 results in increased phagocytosis by lung macrophages, linking mRNA decay to adaptation and immune evasion. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000493275600024 |
WOS关键词 | HOST TEMPERATURE ; BINDING LECTIN ; DECTIN-1 ; DEFENSE ; ADAPTATION ; VIRULENCE ; MANNOSE ; YEAST |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203621 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Buffalo SUNY, Jacobs Sch Med & Biomed Sci, Witebsky Ctr Microbial Pathogenesis & Immunol, Dept Microbiol & Immunol, Buffalo, NY 14203 USA; 2.Univ Buffalo SUNY, New York State Ctr Excellence & Bioinformat, Buffalo, NY 14203 USA |
推荐引用方式 GB/T 7714 | Bloom, Amanda L. M.,Jin, Richard M.,Leipheimer, Jay,et al. Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Bloom, Amanda L. M..,Jin, Richard M..,Leipheimer, Jay.,Bard, Jonathan E..,Yergeau, Donald.,...&Panepinto, John C..(2019).Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming.NATURE COMMUNICATIONS,10. |
MLA | Bloom, Amanda L. M.,et al."Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论