NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma

doi:10.1038/s41467-017-02348-9

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-017-02348-9
	NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma
	Luan, Peipei 1,2; Jian, Weixia 2; Xu, Xu 1; Kou, Wenxin 1; Yu, Qing 1; Hu, Handan 3; Li, Dali 3; Wang, Wei 4; Feinberg, Mark W.5; Zhuang, Jianhui 1; Xu, Yawei 1; Peng, Wenhui 1
	2019-06-28
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2019
卷号	10
文章类型	Article
语种	英语
国家	Peoples R China; USA
英文摘要	NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout (Nlrc5(-/-)) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPAR gamma and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPAR gamma and stimulation of PPAR gamma activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5(-/-) mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPAR gamma.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000473132200046
WOS关键词	MHC CLASS-I ; ACTIVATED-RECEPTOR-GAMMA ; NF-KAPPA-B ; NUCLEOTIDE-BINDING DOMAIN ; FAMILY-MEMBER NLRC5 ; SMOOTH-MUSCLE-CELL ; NOD-LIKE RECEPTORS ; ANTIGEN PRESENTATION ; KEY REGULATOR ; HOST-DEFENSE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203595
专题	资源环境科学
作者单位	1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai 200072, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Endocrinol, Shanghai 200092, Peoples R China; 3.East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci & Sch Life Sci, Shanghai 200241, Peoples R China; 4.Columbia Univ, Med Ctr, Columbia Ctr Translat Immunol, New York, NY 10032 USA; 5.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Cardiovasc Div, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Luan, Peipei,Jian, Weixia,Xu, Xu,et al. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma[J]. NATURE COMMUNICATIONS,2019,10.
APA	Luan, Peipei.,Jian, Weixia.,Xu, Xu.,Kou, Wenxin.,Yu, Qing.,...&Peng, Wenhui.(2019).NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma.NATURE COMMUNICATIONS,10.
MLA	Luan, Peipei,et al."NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma".NATURE COMMUNICATIONS 10(2019).