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DOI | 10.1038/s41467-017-02348-9 |
NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma | |
Luan, Peipei1,2; Jian, Weixia2; Xu, Xu1; Kou, Wenxin1; Yu, Qing1; Hu, Handan3; Li, Dali3; Wang, Wei4; Feinberg, Mark W.5; Zhuang, Jianhui1; Xu, Yawei1; Peng, Wenhui1 | |
2019-06-28 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout (Nlrc5(-/-)) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPAR gamma and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPAR gamma and stimulation of PPAR gamma activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5(-/-) mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPAR gamma. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000473132200046 |
WOS关键词 | MHC CLASS-I ; ACTIVATED-RECEPTOR-GAMMA ; NF-KAPPA-B ; NUCLEOTIDE-BINDING DOMAIN ; FAMILY-MEMBER NLRC5 ; SMOOTH-MUSCLE-CELL ; NOD-LIKE RECEPTORS ; ANTIGEN PRESENTATION ; KEY REGULATOR ; HOST-DEFENSE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203595 |
专题 | 资源环境科学 |
作者单位 | 1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai 200072, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Endocrinol, Shanghai 200092, Peoples R China; 3.East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci & Sch Life Sci, Shanghai 200241, Peoples R China; 4.Columbia Univ, Med Ctr, Columbia Ctr Translat Immunol, New York, NY 10032 USA; 5.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Cardiovasc Div, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Luan, Peipei,Jian, Weixia,Xu, Xu,et al. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Luan, Peipei.,Jian, Weixia.,Xu, Xu.,Kou, Wenxin.,Yu, Qing.,...&Peng, Wenhui.(2019).NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma.NATURE COMMUNICATIONS,10. |
MLA | Luan, Peipei,et al."NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR gamma".NATURE COMMUNICATIONS 10(2019). |
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