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DOI10.1038/s41467-017-02064-4
Sex-specific transcriptional and proteomic signatures in schizophrenia
Tiihonen, Jari1,2; Koskuvi, Marja3,4; Storvik, Markus5; Hyotylainen, Ida3; Gao, Yanyan3; Puttonen, Katja A.3; Giniatullina, Raisa3; Poguzhelskaya, Ekaterina3; Ojansuu, Ilkka2; Vaurio, Olli2; Cannon, Tyrone D.6; Lonnqvist, Jouko7,8; Therman, Sebastian9; Suvisaari, Jaana7; Kaprio, Jaakko10,11; Cheng, Lesley12; Hill, Andrew F.12; Lahteenvuo, Markku2,11; Tohka, Jussi3; Giniatullin, Rashid3; Lehtonen, Sarka3,4; Koistinaho, Jari3,4
2019-09-02
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2019
卷号10
文章类型Article
语种英语
国家Sweden; Finland; USA; Australia
英文摘要

It has remained unclear why schizophrenia typically manifests after adolescence and which neurobiological mechanisms are underlying the cascade leading to the actual onset of the illness. Here we show that the use of induced pluripotent stem cell-derived neurons of monozygotic twins from pairs discordant for schizophrenia enhances disease-specific signal by minimizing genetic heterogeneity. In proteomic and pathway analyses, clinical illness is associated especially with altered glycosaminoglycan, GABAergic synapse, sialylation, and purine metabolism pathways. Although only 12% of all 19,462 genes are expressed differentially between healthy males and females, up to 61% of the illness-related genes are sex specific. These results on sex-specific genes are replicated in another dataset. This implies that the pathophysiology differs between males and females, and may explain why symptoms appear after adolescence when the expression of many sex-specific genes change, and suggests the need for sex-specific treatments.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000483305700010
WOS关键词ANTIPSYCHOTIC TREATMENT ; ASSOCIATION ; METABOLISM ; EXPRESSION ; GENES
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/203584
专题资源环境科学
作者单位1.Karolinska Inst, Dept Clin Neurosci, Byggnad R5, SE-17176 Stockholm, Sweden;
2.Univ Eastern Finland, Niuvanniemi Hosp, Dept Forens Psychiat, Niuvankuja 65, FI-70240 Kuopio, Finland;
3.Univ Eastern Finland, AI Virtanen Inst Mol Sci, POB 1627, FI-70211 Kuopio, Finland;
4.Univ Helsinki, Neurosci Ctr, POB 63, FI-00271 Helsinki, Finland;
5.Univ Eastern Finland, Dept Pharmacol, POB 1627, FI-70211 Kuopio, Finland;
6.Yale Univ, Dept Psychol & Psychiat, 1 Prospect St, New Haven, CT 06511 USA;
7.Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Mental Hlth Unit, POB 30, FI-00271 Helsinki, Finland;
8.Univ Helsinki, Dept Psychiat, POB 22, FI-00014 Helsinki, Finland;
9.Natl Inst Hlth & Welf, Dept Mental Hlth & Subst Abuse Serv, POB 30, FI-00271 Helsinki, Finland;
10.Univ Helsinki, Dept Publ Hlth, POB 20, FI-00014 Helsinki, Finland;
11.Univ Helsinki, Inst Mol Med FIMM, POB 20, FI-00014 Helsinki, Finland;
12.La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem & Genet, Sci Dr, Bundoora, Vic 3083, Australia
推荐引用方式
GB/T 7714
Tiihonen, Jari,Koskuvi, Marja,Storvik, Markus,et al. Sex-specific transcriptional and proteomic signatures in schizophrenia[J]. NATURE COMMUNICATIONS,2019,10.
APA Tiihonen, Jari.,Koskuvi, Marja.,Storvik, Markus.,Hyotylainen, Ida.,Gao, Yanyan.,...&Koistinaho, Jari.(2019).Sex-specific transcriptional and proteomic signatures in schizophrenia.NATURE COMMUNICATIONS,10.
MLA Tiihonen, Jari,et al."Sex-specific transcriptional and proteomic signatures in schizophrenia".NATURE COMMUNICATIONS 10(2019).
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