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DOI | 10.1038/s41467-017-02064-4 |
Sex-specific transcriptional and proteomic signatures in schizophrenia | |
Tiihonen, Jari1,2; Koskuvi, Marja3,4; Storvik, Markus5; Hyotylainen, Ida3; Gao, Yanyan3; Puttonen, Katja A.3; Giniatullina, Raisa3; Poguzhelskaya, Ekaterina3; Ojansuu, Ilkka2; Vaurio, Olli2; Cannon, Tyrone D.6; Lonnqvist, Jouko7,8; Therman, Sebastian9; Suvisaari, Jaana7; Kaprio, Jaakko10,11; Cheng, Lesley12; Hill, Andrew F.12; Lahteenvuo, Markku2,11; Tohka, Jussi3; Giniatullin, Rashid3; Lehtonen, Sarka3,4; Koistinaho, Jari3,4 | |
2019-09-02 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Finland; USA; Australia |
英文摘要 | It has remained unclear why schizophrenia typically manifests after adolescence and which neurobiological mechanisms are underlying the cascade leading to the actual onset of the illness. Here we show that the use of induced pluripotent stem cell-derived neurons of monozygotic twins from pairs discordant for schizophrenia enhances disease-specific signal by minimizing genetic heterogeneity. In proteomic and pathway analyses, clinical illness is associated especially with altered glycosaminoglycan, GABAergic synapse, sialylation, and purine metabolism pathways. Although only 12% of all 19,462 genes are expressed differentially between healthy males and females, up to 61% of the illness-related genes are sex specific. These results on sex-specific genes are replicated in another dataset. This implies that the pathophysiology differs between males and females, and may explain why symptoms appear after adolescence when the expression of many sex-specific genes change, and suggests the need for sex-specific treatments. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483305700010 |
WOS关键词 | ANTIPSYCHOTIC TREATMENT ; ASSOCIATION ; METABOLISM ; EXPRESSION ; GENES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203584 |
专题 | 资源环境科学 |
作者单位 | 1.Karolinska Inst, Dept Clin Neurosci, Byggnad R5, SE-17176 Stockholm, Sweden; 2.Univ Eastern Finland, Niuvanniemi Hosp, Dept Forens Psychiat, Niuvankuja 65, FI-70240 Kuopio, Finland; 3.Univ Eastern Finland, AI Virtanen Inst Mol Sci, POB 1627, FI-70211 Kuopio, Finland; 4.Univ Helsinki, Neurosci Ctr, POB 63, FI-00271 Helsinki, Finland; 5.Univ Eastern Finland, Dept Pharmacol, POB 1627, FI-70211 Kuopio, Finland; 6.Yale Univ, Dept Psychol & Psychiat, 1 Prospect St, New Haven, CT 06511 USA; 7.Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Mental Hlth Unit, POB 30, FI-00271 Helsinki, Finland; 8.Univ Helsinki, Dept Psychiat, POB 22, FI-00014 Helsinki, Finland; 9.Natl Inst Hlth & Welf, Dept Mental Hlth & Subst Abuse Serv, POB 30, FI-00271 Helsinki, Finland; 10.Univ Helsinki, Dept Publ Hlth, POB 20, FI-00014 Helsinki, Finland; 11.Univ Helsinki, Inst Mol Med FIMM, POB 20, FI-00014 Helsinki, Finland; 12.La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem & Genet, Sci Dr, Bundoora, Vic 3083, Australia |
推荐引用方式 GB/T 7714 | Tiihonen, Jari,Koskuvi, Marja,Storvik, Markus,et al. Sex-specific transcriptional and proteomic signatures in schizophrenia[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Tiihonen, Jari.,Koskuvi, Marja.,Storvik, Markus.,Hyotylainen, Ida.,Gao, Yanyan.,...&Koistinaho, Jari.(2019).Sex-specific transcriptional and proteomic signatures in schizophrenia.NATURE COMMUNICATIONS,10. |
MLA | Tiihonen, Jari,et al."Sex-specific transcriptional and proteomic signatures in schizophrenia".NATURE COMMUNICATIONS 10(2019). |
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