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DOI | 10.1038/s41467-017-02142-7 |
Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis | |
Kidoya, Hiroyasu1; Muramatsu, Fumitaka1; Shimamura, Teppei2; Jia, Weizhen1; Satoh, Takashi3; Hayashi, Yumiko1; Naito, Hisamichi1; Kunisaki, Yuya4; Arai, Fumio4; Seki, Masahide5; Suzuki, Yutaka5; Osawa, Tsuyoshi6; Akira, Shizuo3,7; Takakura, Nobuyuki1 | |
2019-03-06 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | The balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) maintains hematopoietic homeostasis, failure of which can lead to hematopoietic disorder. HSPC fate is controlled by signals from the bone marrow niche resulting in alteration of the stem cell transcription network. Regnase-1, a member of the CCCH zinc finger protein family possessing RNAse activity, mediates post-transcriptional regulatory activity through degradation of target mRNAs. The precise function of Regnase-1 has been explored in inflammation-related cytokine expression but its function in hematopoiesis has not been elucidated. Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA. In addition, we found that dysfunction of Regnase-1 leads to the rapid onset of abnormal hematopoiesis. Thus, our data reveal that Regnase-1-mediated post-transcriptional regulation is required for HSPC maintenance and suggest that it represents a leukemia tumor suppressor. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000460409300003 |
WOS关键词 | TRANSCRIPTION FACTOR ; SELF-RENEWAL ; BONE-MARROW ; MESSENGER-RNA ; T-CELLS ; EXPRESSION ; DIFFERENTIATION ; DEGRADATION ; COMPARTMENT ; MECHANISMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203575 |
专题 | 资源环境科学 |
作者单位 | 1.Osaka Univ, Dept Signal Transduct, Microbial Dis Res Inst, 3-1 Yamada Oka, Suita, Osaka 5650871, Japan; 2.Nagoya Univ, Grad Sch Med, Div Syst Biol, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan; 3.Osaka Univ, Dept Host Def, Microbial Dis Res Inst, 3-1 Yamada Oka, Suita, Osaka 5650871, Japan; 4.Kyushu Univ, Dept Stem Cell Biol & Med Canc Stem Cell Res, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan; 5.Univ Tokyo, Dept Med Genome Sci, Grad Sch Frontier Sci, Chiba 2778561, Japan; 6.Univ Tokyo, Div Integrat Nutr & Oncol, Res Ctr Adv Sci & Technol, Meguro Ku, 4-6-1 Komaba, Tokyo 1538904, Japan; 7.Osaka Univ, Host Def Lab, World Premier Inst, Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan |
推荐引用方式 GB/T 7714 | Kidoya, Hiroyasu,Muramatsu, Fumitaka,Shimamura, Teppei,et al. Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Kidoya, Hiroyasu.,Muramatsu, Fumitaka.,Shimamura, Teppei.,Jia, Weizhen.,Satoh, Takashi.,...&Takakura, Nobuyuki.(2019).Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.NATURE COMMUNICATIONS,10. |
MLA | Kidoya, Hiroyasu,et al."Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis".NATURE COMMUNICATIONS 10(2019). |
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