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DOI | 10.1038/s41467-017-01931-4 |
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome | |
Kong, Byoungjae1; Moon, Seokoh1; Kim, Yuna1; Heo, Paul1; Jung, Younghun1; Yu, Seok-Hyeon1; Chung, Jinhyo1; Ban, Choongjin1; Kim, Yong Ho2; Kim, Paul3; Hwang, Beom Jeung3; Chung, Woo-Jae1; Shin, Yeon-Kyun4; Seong, Baik Lin3; Kweon, Dae-Hyuk1,2 | |
2019-01-14 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | South Korea; USA |
英文摘要 | Membrane-disrupting agents that selectively target virus versus host membranes could potentially inhibit a broad-spectrum of enveloped viruses, but currently such antivirals are lacking. Here, we develop a nanodisc incorporated with a decoy virus receptor that inhibits virus infection. Mechanistically, nanodiscs carrying the viral receptor sialic acid bind to influenza virions and are co-endocytosed into host cells. At low pH in the endosome, the nanodiscs rupture the viral envelope, trapping viral RNAs inside the endolysosome for enzymatic decomposition. In contrast, liposomes containing a decoy receptor show weak antiviral activity due to the lack of membrane disruption. The nanodiscs inhibit influenza virus infection and reduce morbidity and mortality in a mouse model. Our results suggest a new class of antivirals applicable to other enveloped viruses that cause irreversible physical damage specifically to virus envelope by viruses' own fusion machine. In conclusion, the lipid nanostructure provides another dimension for antiviral activity of decoy molecules. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455595400008 |
WOS关键词 | INFLUENZA-VIRUS HEMAGGLUTININ ; MONOCLONAL-ANTIBODY ; FUSION ; CELL ; NANOPARTICLES ; INFECTION ; EFFICACY ; ENTRY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203565 |
专题 | 资源环境科学 |
作者单位 | 1.Sungkyunkwan Univ, Coll Biotechnol & Bioengn, Dept Integrat Biotechnol, Suwon 16419, South Korea; 2.Sungkyunkwan Univ, Biomed Inst Convergence, Suwon 16419, South Korea; 3.Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South Korea; 4.Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA |
推荐引用方式 GB/T 7714 | Kong, Byoungjae,Moon, Seokoh,Kim, Yuna,et al. Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Kong, Byoungjae.,Moon, Seokoh.,Kim, Yuna.,Heo, Paul.,Jung, Younghun.,...&Kweon, Dae-Hyuk.(2019).Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome.NATURE COMMUNICATIONS,10. |
MLA | Kong, Byoungjae,et al."Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome".NATURE COMMUNICATIONS 10(2019). |
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