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DOI | 10.1038/s41467-017-01226-8 |
In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance | |
Haunreiter, Vanina Dengler1; Boumasmoud, Mathilde1; Haffner, Nicola1; Wipfli, Dennis1; Leimer, Nadja1,6; Rachmuhl, Carole1,7; Kuhnert, Denise1,8; Achermann, Yvonne1; Zbinden, Reinhard2; Benussi, Stefano3; Vulin, Clement4,5; Zinkernagel, Annelies S.1 | |
2019-03-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; USA; Germany |
英文摘要 | Treatment failure in biofilm-associated bacterial infections is an important healthcare issue. In vitro studies and mouse models suggest that bacteria enter a slow-growing/non-growing state that results in transient tolerance to antibiotics in the absence of a specific resistance mechanism. However, little clinical confirmation of antibiotic tolerant bacteria in patients exists. In this study we investigate a Staphylococcus epidermidis pacemaker-associated endocarditis, in a patient who developed a break-through bacteremia despite taking antibiotics to which the S. epidermidis isolate is fully susceptible in vitro. Characterization of the clinical S. epidermidis isolates reveals in-host evolution over the 16-week infection period, resulting in increased antibiotic tolerance of the entire population due to a prolonged lag time until growth resumption and a reduced growth rate. Furthermore, we observe adaptation towards an increased biofilm formation capacity and genetic diversification of the S. epidermidis isolates within the patient. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000460632100004 |
WOS关键词 | BIOFILM FORMATION ; RESISTANCE ; PERSISTENCE ; AUREUS ; IDENTIFICATION ; TIME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203549 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, CH-8091 Zurich, Switzerland; 2.Univ Zurich, Inst Med Microbiol, CH-8006 Zurich, Switzerland; 3.Univ Zurich, Univ Zurich Hosp, Univ Heart Ctr, Dept Cardiac Surg, CH-8091 Zurich, Switzerland; 4.Swiss Fed Inst Technol, Inst Biogeochem & Pollutant Dynam, CH-8092 Zurich, Switzerland; 5.Eawag, Dept Environm Microbiol, CH-8600 Dubendorf, Switzerland; 6.Northeastern Univ, Dept Biol, Antimicrobial Discovery Ctr, Boston, MA 02115 USA; 7.Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland; 8.Max Planck Inst Sci Human Hist, D-07745 Jena, Germany |
推荐引用方式 GB/T 7714 | Haunreiter, Vanina Dengler,Boumasmoud, Mathilde,Haffner, Nicola,et al. In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Haunreiter, Vanina Dengler.,Boumasmoud, Mathilde.,Haffner, Nicola.,Wipfli, Dennis.,Leimer, Nadja.,...&Zinkernagel, Annelies S..(2019).In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance.NATURE COMMUNICATIONS,10. |
MLA | Haunreiter, Vanina Dengler,et al."In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance".NATURE COMMUNICATIONS 10(2019). |
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