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DOI | 10.1038/s41467-017-01806-8 |
Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS | |
Chung, Yuhee1; Zhu, Yang1; Wu, Miin-Feng1,4; Simonini, Sara2,5; Kuhn, Andre2; Armenta-Medina, Alma3; Jin, Run1; Ostergaard, Lars2; Gillmor, C. Stewart3; Wagner, Doris1 | |
2019-02-21 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England; Mexico; Switzerland |
英文摘要 | Specification of new organs from transit amplifying cells is critical for higher eukaryote development. In plants, a central stem cell pool maintained by the pluripotency factor SHOOTMERISTEMLESS (STM), is surrounded by transit amplifying cells competent to respond to auxin hormone maxima by giving rise to new organs. Auxin triggers flower initiation through Auxin Response Factor (ARF) MONOPTEROS (MP) and recruitment of chromatin remodelers to activate genes promoting floral fate. The contribution of gene repression to reproductive primordium initiation is poorly understood. Here we show that downregulation of the STM pluripotency gene promotes initiation of flowers and uncover the mechanism for STM silencing. The ARFs ETTIN (ETT) and ARF4 promote organogenesis at the reproductive shoot apex in parallel with MP via histone-deacetylation mediated transcriptional silencing of STM. ETT and ARF4 directly repress STM, while MP acts indirectly, through its target FILAMENTOUS FLOWER (FIL). Our data suggest that - as in animals-downregulation of the pluripotency program is important for organogenesis in plants. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000459284600003 |
WOS关键词 | KNOX HOMEOBOX GENES ; TRANSCRIPTIONAL REPRESSION ; CELL FATE ; REGULATORY PROTEINS ; ARABIDOPSIS ; EXPRESSION ; FLOWER ; MERISTEM ; TOPLESS ; INITIATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203548 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Penn, Dept Biol, Philadelphia, PA 19104 USA; 2.John Innes Ctr, Crop Genet Dept, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England; 3.IPN, CINVESTAV, Ctr Invest & Estudios Avanzados, Unidad Genom Avanzada,Lab Nacl Genom Biodiversida, Guanajuato 36824, Mexico; 4.Bayer Crop Sci, St Louis, MO 63146 USA; 5.Univ Zurich, Dept Plant & Microbial Biol, Zollikerstr 107, CH-8008 Zurich, Switzerland |
推荐引用方式 GB/T 7714 | Chung, Yuhee,Zhu, Yang,Wu, Miin-Feng,et al. Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Chung, Yuhee.,Zhu, Yang.,Wu, Miin-Feng.,Simonini, Sara.,Kuhn, Andre.,...&Wagner, Doris.(2019).Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS.NATURE COMMUNICATIONS,10. |
MLA | Chung, Yuhee,et al."Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS".NATURE COMMUNICATIONS 10(2019). |
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