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DOI | 10.1038/s41467-017-01831-7 |
Primed histone demethylation regulates shoot regenerative competency | |
Ishihara, Hiroya1; Sugimoto, Kaoru1; Tarr, Paul T.2,3; Temman, Haruka1; Kadokura, Satoshi1; Inui, Yayoi1; Sakamoto, Takuya1; Sasaki, Taku4; Aida, Mitsuhiro1; Suzuki, Takamasa5; Inagaki, Soichi6,7,8; Morohashi, Kengo1; Seki, Motoaki4,9; Kakutani, Tetsuji6,8,10; Meyerowitz, Elliot M.2,3; Matsunaga, Sachihiro1 | |
2019-04-16 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan; USA |
英文摘要 | Acquisition of pluripotency by somatic cells is a striking process that enables multicellular organisms to regenerate organs. This process includes silencing of genes to erase original tissue memory and priming of additional cell type specification genes, which are then poised for activation by external signal inputs. Here, through analysis of genome-wide histone modifications and gene expression profiles, we show that a gene priming mechanism involving LYSINE-SPECIFIC DEMETHYLASE 1-LIKE 3 (LDL3) specifically eliminates H3K4me2 during formation of the intermediate pluripotent cell mass known as callus derived from Arabidopsis root cells. While LDL3-mediated H3K4me2 removal does not immediately affect gene expression, it does facilitate the later activation of genes that act to form shoot progenitors when external cues lead to shoot induction. These results give insights into the role of H3K4 methylation in plants, and into the primed state that provides plant cells with high regenerative competency. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464655900001 |
WOS关键词 | TISSUE-SPECIFIC ENHANCERS ; MEDIATED TRANSFORMATION ; GENE-EXPRESSION ; KINASE CIPK23 ; ROOT EXPLANTS ; ARABIDOPSIS ; CHROMATIN ; LSD1 ; H3 ; PLURIPOTENCY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203545 |
专题 | 资源环境科学 |
作者单位 | 1.Tokyo Univ Sci, Fac Sci & Technol, Dept Appl Biol Sci, 2641 Yamazaki, Noda, Chiba 2788510, Japan; 2.CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA; 3.CALTECH, Div Biol & Biol Engn 156 29, Pasadena, CA 91125 USA; 4.RIKEN Ctr Sustainable Resource Sci, Plant Genom Network Res Team, 1-7-22 Suehiro, Yokohama, Kanagawa 2300045, Japan; 5.Chubu Univ, Coll Biosci & Biotechnol, 1200 Matsumoto Cho, Kasugai, Aichi 4878501, Japan; 6.Natl Inst Genet, 1111 Yata, Mishima, Shizuoka 4118540, Japan; 7.Japan Sci & Technol Agcy, PREST, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan; 8.Grad Univ Adv Studies SOKENDAI, Sch Life Sci, Dept Genet, Mishima, Shizuoka 4118540, Japan; 9.RIKEN Cluster Pioneering Res, Plant Epigenome Regulat Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; 10.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, Tokyo 1130033, Japan |
推荐引用方式 GB/T 7714 | Ishihara, Hiroya,Sugimoto, Kaoru,Tarr, Paul T.,et al. Primed histone demethylation regulates shoot regenerative competency[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Ishihara, Hiroya.,Sugimoto, Kaoru.,Tarr, Paul T..,Temman, Haruka.,Kadokura, Satoshi.,...&Matsunaga, Sachihiro.(2019).Primed histone demethylation regulates shoot regenerative competency.NATURE COMMUNICATIONS,10. |
MLA | Ishihara, Hiroya,et al."Primed histone demethylation regulates shoot regenerative competency".NATURE COMMUNICATIONS 10(2019). |
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