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| DOI | 10.1038/s41467-017-01532-1 |
| The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models | |
| Martinez-Velez, Naiara1,2,3; Garcia-Moure, Marc1,2,3; Marigil, Miguel1,2,3; Gonzalez-Huarriz, Marisol1,2,3; Puigdelloses, Montse1,2,4; Gallego Perez-Larraya, Jaime1,2,4; Zalacain, Marta1,2,3; Marrodan, Lucia1,2,3; Varela-Guruceaga, Maider1,2,3; Laspidea, Virginia1,2,3; Javier Aristu, Jose1,5; Isaac Ramos, Luis1,5; Tejada-Solis, Sonia1,6; Diez-Valle, Ricardo1,6; Jones, Chris7,8; Mackay, Alan7,8; Martinez-Climent, Jose A.1,9; Jose Garcia-Barchino, Maria1,9; Raabe, Eric10,11; Monje, Michelle12; Becher, Oren J.13,14; Junier, Marie Pierre15; El-Habr, Elias A.15; Chneiweiss, Herve15; Aldave, Guillermo16; Jiang, Hong17; Fueyo, Juan17,18; Patino-Garcia, Ana1,2,3; Gomez-Manzano, Candelaria17; Alonso, Marta M.1,2,3 | |
| 2019-05-28 | |
| 发表期刊 | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| 出版年 | 2019 |
| 卷号 | 10 |
| 文章类型 | Article |
| 语种 | 英语 |
| 国家 | Spain; England; USA; France |
| 英文摘要 | Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic virotherapy is emerging as a solid therapeutic approach. Delta-24-RGD is a replication competent adenovirus engineered to replicate in tumor cells with an aberrant RB pathway. This virus has proven to be safe and effective in adult gliomas. Here we report that the administration of Delta-24-RGD is safe in mice and results in a significant increase in survival in immunodeficient and immunocompetent models of pHGG and DIPGs. Our results show that the Delta-24-RGD antiglioma effect is mediated by the oncolytic effect and the immune response elicited against the tumor. Altogether, our data highlight the potential of this virus as treatment for patients with these tumors. Of clinical significance, these data have led to the start of a phase I/II clinical trial at our institution for newly diagnosed DIPG (NCT03178032). |
| 领域 | 资源环境 |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000469221000001 |
| WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; HIGH-GRADE ; HERPES-VIRUS ; BRAIN-TUMOR ; SURVIVAL ; ADENOVIRUS ; REPLICATION ; CHILDHOOD ; EFFICACY ; TRIAL |
| WOS类目 | Multidisciplinary Sciences |
| WOS研究方向 | Science & Technology - Other Topics |
| URL | 查看原文 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203544 |
| 专题 | 资源环境科学 |
| 作者单位 | 1.Hlth Res Inst Navarra IDISNA, Pamplona, Navarra, Spain; 2.Univ Navarra, Program Solid Tumors, Ctr Appl Med Res CIMA, Pamplona, Navarra, Spain; 3.Clin Univ Navarra, Dept Pediat, Pamplona, Spain; 4.Clin Univ Navarra, Dept Neurol, Pamplona, Spain; 5.Clin Univ Navarra, Dept Radiat Oncol, Pamplona, Spain; 6.Clin Univ Navarra, Dept Neurosurg, Pamplona, Spain; 7.Inst Canc Res, Div Mol Pathol, 15 Cotswold Rd, London SM2 5NG, Surrey, England; 8.Inst Canc Res, Div Canc Therapeut, 15 Cotswold Rd, London SM2 5NG, Surrey, England; 9.Univ Navarra, Ctr Appl Med Res CIMA, CIBERONC, Div Hematopoiet Tumors, Pamplona, Navarra, Spain; 10.Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA; 11.Johns Hopkins Univ, Sch Med, Div Pediat Oncol, Baltimore, MD USA; 12.Stanford Univ, Sch Med, Dept Neurol, Stanford, CA 94305 USA; 13.Northwestern Univ, Dept Pediat, Chicago, IL 60611 USA; 14.Ann & Robert H Lurie Childrens Hosp Chicago, Div Pediat Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA; 15.Sorbonne Univ, CNRS, Neurosci Paris Seine IBPS, INSERM,UMR8246,U1130, Paris, France; 16.Texas Childrens Hosp, Baylor Coll Med, Dept Surg, Div Pediat Neurosurg, Houston, TX 77030 USA; 17.Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA; 18.Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Martinez-Velez, Naiara,Garcia-Moure, Marc,Marigil, Miguel,et al. The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models[J]. NATURE COMMUNICATIONS,2019,10. |
| APA | Martinez-Velez, Naiara.,Garcia-Moure, Marc.,Marigil, Miguel.,Gonzalez-Huarriz, Marisol.,Puigdelloses, Montse.,...&Alonso, Marta M..(2019).The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models.NATURE COMMUNICATIONS,10. |
| MLA | Martinez-Velez, Naiara,et al."The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models".NATURE COMMUNICATIONS 10(2019). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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