Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-017-01410-w |
Dynamic control of enhancer activity drives stage-specific gene expression during flower morphogenesis | |
Yan, Wenhao1; Chen, Dijun1,2; Schumacher, Julia1,2; Durantini, Diego2,5; Engelhorn, Julia3,6,7; Chen, Ming4; Carles, Cristel C.3; Kaufmann, Kerstin1 | |
2019-04-12 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; France; Peoples R China |
英文摘要 | Enhancers are critical for developmental stage-specific gene expression, but their dynamic regulation in plants remains poorly understood. Here we compare genome-wide localization of H3K27ac, chromatin accessibility and transcriptomic changes during flower development in Arabidopsis. H3K27ac prevalently marks promoter-proximal regions, suggesting that H3K27ac is not a hallmark for enhancers in Arabidopsis. We provide computational and experimental evidence to confirm that distal DNase. hypersensitive sites are predictive of enhancers. The predicted enhancers are highly stage-specific across flower development, significantly associated with SNPs for flowering-related phenotypes, and conserved across crucifer species. Through the integration of genome-wide transcription factor (TF) binding datasets, we find that floral master regulators and stage-specific TFs are largely enriched at developmentally dynamic enhancers. Finally, we show that enhancer clusters and intronic enhancers significantly associate with stage-specific gene regulation by floral master TFs. Our study provides insights into the functional flexibility of enhancers during plant development, as well as hints to annotate plant enhancers. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464338100016 |
WOS关键词 | GENOME-WIDE ANALYSIS ; TRANSCRIPTION FACTORS ; OPEN CHROMATIN ; CHIP-SEQ ; HISTONE MODIFICATIONS ; SUPER-ENHANCERS ; CELL IDENTITY ; DNA ELEMENTS ; IDENTIFICATION ; SIGNATURES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203521 |
专题 | 资源环境科学 |
作者单位 | 1.Humboldt Univ, Inst Biol, Dept Plant Cell & Mol Biol, D-10115 Berlin, Germany; 2.Univ Potsdam, Inst Biochem & Biol, D-14476 Potsdam, Germany; 3.UGA, CNRS, CEA, INRA,IRIG LPCV, F-38000 Grenoble, France; 4.Zhejiang Univ, Dept Bioinformat, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China; 5.Ernst Benary Samenzucht GmbH, Friedrich Benary Weg, D-134346 Munden, Muenden, Germany; 6.Max Planck Inst Plant Breeding Res, Carl von Linne Weg 10, D-50829 Cologne, Germany; 7.Heinrich Heine Univ, Inst Mol Physiol, D-40225 Dusseldorf, Germany |
推荐引用方式 GB/T 7714 | Yan, Wenhao,Chen, Dijun,Schumacher, Julia,et al. Dynamic control of enhancer activity drives stage-specific gene expression during flower morphogenesis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Yan, Wenhao.,Chen, Dijun.,Schumacher, Julia.,Durantini, Diego.,Engelhorn, Julia.,...&Kaufmann, Kerstin.(2019).Dynamic control of enhancer activity drives stage-specific gene expression during flower morphogenesis.NATURE COMMUNICATIONS,10. |
MLA | Yan, Wenhao,et al."Dynamic control of enhancer activity drives stage-specific gene expression during flower morphogenesis".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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