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DOI | 10.1038/s41467-017-01681-3 |
Recollection in the human hippocampal-entorhinal cell circuitry | |
Staresina, Bernhard P.1,2; Reber, Thomas P.3,4; Niediek, Johannes3; Bostrom, Jan5; Elger, Christian E.3; Mormann, Florian3 | |
2019-04-03 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Germany; Switzerland |
英文摘要 | Imagine how flicking through your photo album and seeing a picture of a beach sunset brings back fond memories of a tasty cocktail you had that night. Computational models suggest that upon receiving a partial memory cue ('beach'), neurons in the hippocampus coordinate reinstatement of associated memories ('cocktail') in cortical target sites. Here, using human single neuron recordings, we show that hippocampal firing rates are elevated from similar to 500-1500 ms after cue onset during successful associative retrieval. Concurrently, the retrieved target object can be decoded from population spike patterns in adjacent entorhinal cortex (EC), with hippocampal firing preceding EC spikes and predicting the fidelity of EC object reinstatement. Prior to orchestrating reinstatement, a separate population of hippocampal neurons distinguishes different scene cues (buildings vs. landscapes). These results elucidate the hippocampal-entorhinal circuit dynamics for memory recall and reconcile disparate views on the role of the hippocampus in scene processing vs. associative memory. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000463170600002 |
WOS关键词 | MEDIAL TEMPORAL-LOBE ; SINGLE NEURONS ; EPISODIC MEMORY ; REPRESENTATION ; RESPONSES ; AMYGDALA ; RECOGNITION ; RETRIEVAL ; CORTEX ; REPLAY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203512 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England; 2.Univ Birmingham, Ctr Human Brain Hlth, Birmingham B15 2TT, W Midlands, England; 3.Univ Bonn, Dept Epileptol, Med Ctr, D-53175 Bonn, Germany; 4.Swiss Distance Learning Univ, Fac Psychol, CH-3900 Brig, Switzerland; 5.Univ Bonn, Med Ctr, Dept Neurosurg, D-53175 Bonn, Germany |
推荐引用方式 GB/T 7714 | Staresina, Bernhard P.,Reber, Thomas P.,Niediek, Johannes,et al. Recollection in the human hippocampal-entorhinal cell circuitry[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Staresina, Bernhard P.,Reber, Thomas P.,Niediek, Johannes,Bostrom, Jan,Elger, Christian E.,&Mormann, Florian.(2019).Recollection in the human hippocampal-entorhinal cell circuitry.NATURE COMMUNICATIONS,10. |
MLA | Staresina, Bernhard P.,et al."Recollection in the human hippocampal-entorhinal cell circuitry".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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